HCSGD entry for RRN3

1. General information

Official gene symbolRRN3
Entrez ID54700
Gene full nameRRN3 RNA polymerase I transcription factor homolog (S. cerevisiae)
Other gene symbolsA-270G1.2 TIFIA
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001701In utero embryonic developmentIEAbiological_process
GO:0003743Translation initiation factor activityIEAmolecular_function
GO:0005654NucleoplasmTAScellular_component
GO:0005730NucleolusIDAcellular_component
GO:0006360Transcription from RNA polymerase I promoterTASbiological_process
GO:0006361Transcription initiation from RNA polymerase I promoterIEA TASbiological_process
GO:0007000Nucleolus organizationIEAbiological_process
GO:0007028Cytoplasm organizationIEAbiological_process
GO:0008283Cell proliferationIEAbiological_process
GO:0010467Gene expressionTASbiological_process
GO:0042254Ribosome biogenesisIEAbiological_process
GO:0045893Positive regulation of transcription, DNA-templatedIEAbiological_process
GO:0048872Homeostasis of number of cellsIEAbiological_process
GO:0070063RNA polymerase bindingIEAmolecular_function
GO:1902254Negative regulation of intrinsic apoptotic signaling pathway by p53 class mediatorIEAbiological_process
GO:2000142Regulation of DNA-templated transcription, initiationIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.00829925530.94291098740.23583372841.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.5950737062
GSE13712_SHEARUp0.5143103557
GSE13712_STATICUp0.1012373604
GSE19018Down-0.8245845579
GSE19899_A1Up1.1520995767
GSE19899_A2Up1.0184564616
PubMed_21979375_A1Up1.4392213565
PubMed_21979375_A2Up0.8989732006
GSE35957Up0.1110976156
GSE36640Up0.1436747139
GSE54402Up0.4074526441
GSE9593Up0.0717041647
GSE43922Up0.8736403740
GSE24585Down-0.2280082373
GSE37065Up0.2310349443
GSE28863_A1--
GSE28863_A2--
GSE28863_A3--
GSE28863_A4--
GSE48662Down-0.2068455706

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-93-5pMIMAT0000093MIRT028106SequencingFunctional MTI (Weak)20371350
hsa-miR-191-5pMIMAT0000440MIRT045801CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.