HCSGD entry for CROT
1. General information
| Official gene symbol | CROT |
|---|---|
| Entrez ID | 54677 |
| Gene full name | carnitine O-octanoyltransferase |
| Other gene symbols | COT |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005102 | Receptor binding | IPI | molecular_function |
| GO:0005739 | Mitochondrion | IEA | cellular_component |
| GO:0005777 | Peroxisome | IDA NAS | cellular_component |
| GO:0005782 | Peroxisomal matrix | TAS | cellular_component |
| GO:0006091 | Generation of precursor metabolites and energy | IDA | biological_process |
| GO:0006631 | Fatty acid metabolic process | IMP | biological_process |
| GO:0006635 | Fatty acid beta-oxidation | IDA | biological_process |
| GO:0008458 | Carnitine O-octanoyltransferase activity | IDA | molecular_function |
| GO:0015908 | Fatty acid transport | IEA | biological_process |
| GO:0016746 | Transferase activity, transferring acyl groups | IEA | molecular_function |
| GO:0033540 | Fatty acid beta-oxidation using acyl-CoA oxidase | TAS | biological_process |
| GO:0043231 | Intracellular membrane-bounded organelle | IDA | cellular_component |
| GO:0044255 | Cellular lipid metabolic process | TAS | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0051791 | Medium-chain fatty acid metabolic process | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.5225815205 | 0.0591028152 | 0.9999902473 | 0.4579467766 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.2402573939 |
| GSE13712_SHEAR | Down | -0.0651007386 |
| GSE13712_STATIC | Up | 0.1596639613 |
| GSE19018 | Down | -1.0057344879 |
| GSE19899_A1 | Up | 0.2853067867 |
| GSE19899_A2 | Down | -0.6800766210 |
| PubMed_21979375_A1 | Down | -0.9148511687 |
| PubMed_21979375_A2 | Down | -0.0945047222 |
| GSE35957 | Up | 0.0761893930 |
| GSE36640 | Up | 0.0847152093 |
| GSE54402 | Down | -0.5091492707 |
| GSE9593 | Down | -0.1362535524 |
| GSE43922 | Up | 0.0099945465 |
| GSE24585 | Up | 0.4773901055 |
| GSE37065 | Up | 0.2089371947 |
| GSE28863_A1 | Down | -0.0805673118 |
| GSE28863_A2 | Up | 0.4582882699 |
| GSE28863_A3 | Down | -0.7870348138 |
| GSE28863_A4 | Down | -0.0730566851 |
| GSE48662 | Down | -0.4070930931 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| L-Carnitine | DB00583 | APRD01070 |
| (3-Carboxy-2-(R)-Hydroxy-Propyl)-Trimethyl-Ammonium | DB02648 | EXPT00038 |
| 3-Carboxy-N,N,N-Trimethyl-2-(Octanoyloxy)Propan-1-Aminium | DB03832 | EXPT02414 |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-33a-5p | MIMAT0000091 | MIRT007354 | Immunofluorescence//Luciferase reporter assay//Western blot | Functional MTI | 23547260 |
| hsa-miR-106b-5p | MIMAT0000680 | MIRT020476 | Microarray | Functional MTI (Weak) | 17242205 |
| hsa-miR-221-3p | MIMAT0000278 | MIRT046842 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
