HCSGD entry for UGT1A1

1. General information

Official gene symbolUGT1A1
Entrez ID54658
Gene full nameUDP glucuronosyltransferase 1 family, polypeptide A1
Other gene symbolsBILIQTL1 GNT1 HUG-BR1 UDPGT UDPGT 1-1 UGT1 UGT1A
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001889Liver developmentIEAbiological_process
GO:0001972Retinoic acid bindingIDAmolecular_function
GO:0004857Enzyme inhibitor activityIDAmolecular_function
GO:0005496Steroid bindingIDAmolecular_function
GO:0005789Endoplasmic reticulum membraneTAScellular_component
GO:0005887Integral component of plasma membraneIEAcellular_component
GO:0006778Porphyrin-containing compound metabolic processTASbiological_process
GO:0006789Bilirubin conjugationTASbiological_process
GO:0006805Xenobiotic metabolic processTASbiological_process
GO:0006953Acute-phase responseIEAbiological_process
GO:0007584Response to nutrientIEAbiological_process
GO:0007586DigestionNASbiological_process
GO:0008202Steroid metabolic processICbiological_process
GO:0008210Estrogen metabolic processTASbiological_process
GO:0015020Glucuronosyltransferase activityIDA TASmolecular_function
GO:0016758Transferase activity, transferring hexosyl groupsIEAmolecular_function
GO:0017144Drug metabolic processICbiological_process
GO:0019899Enzyme bindingIDAmolecular_function
GO:0031100Organ regenerationIEAbiological_process
GO:0032496Response to lipopolysaccharideIEAbiological_process
GO:0042167Heme catabolic processTASbiological_process
GO:0042493Response to drugIEAbiological_process
GO:0042573Retinoic acid metabolic processICbiological_process
GO:0042594Response to starvationIEAbiological_process
GO:0042803Protein homodimerization activityIPImolecular_function
GO:0043086Negative regulation of catalytic activityIDAbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0045939Negative regulation of steroid metabolic processICbiological_process
GO:0046483Heterocycle metabolic processICbiological_process
GO:0046982Protein heterodimerization activityIPImolecular_function
GO:0050790Regulation of catalytic activityIDAbiological_process
GO:0051552Flavone metabolic processIDAbiological_process
GO:0052695Cellular glucuronidationTASbiological_process
GO:0052696Flavonoid glucuronidationIDAbiological_process
GO:0052697Xenobiotic glucuronidationIDAbiological_process
GO:0070069Cytochrome complexIEAcellular_component
GO:0070980Biphenyl catabolic processIEAbiological_process
GO:0071361Cellular response to ethanolIEAbiological_process
GO:0071385Cellular response to glucocorticoid stimulusIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.67175123670.89755809050.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0463968285
GSE13712_SHEARUp0.0667928478
GSE13712_STATICUp0.0635425789
GSE19018Down-0.0035067190
GSE19899_A1Down-0.0318288401
GSE19899_A2Up0.3111285528
PubMed_21979375_A1Up0.0387736447
PubMed_21979375_A2Down-0.0584916653
GSE35957Up0.0345952811
GSE36640Up0.0681773591
GSE54402Up0.1170599536
GSE9593Up0.0441613958
GSE43922--
GSE24585--
GSE37065--
GSE28863_A1Down-0.0429284125
GSE28863_A2Up0.1164869773
GSE28863_A3Up0.1442064281
GSE28863_A4Down-0.0528566549
GSE48662--

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.