HCSGD entry for INO80

1. General information

Official gene symbolINO80
Entrez ID54617
Gene full nameINO80 homolog (S. cerevisiae)
Other gene symbolsINO80A INOC1 hINO80
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000070Mitotic sister chromatid segregationIMPbiological_process
GO:0000724Double-strand break repair via homologous recombinationIMPbiological_process
GO:0003677DNA bindingIDA IEAmolecular_function
GO:0003678DNA helicase activityIDAmolecular_function
GO:0003779Actin bindingIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005874MicrotubuleIEAcellular_component
GO:0006200ATP catabolic processIDAbiological_process
GO:0006302Double-strand break repairIMPbiological_process
GO:0006338Chromatin remodelingIDAbiological_process
GO:0010571Positive regulation of nuclear cell cycle DNA replicationIMPbiological_process
GO:0016817Hydrolase activity, acting on acid anhydridesIEAmolecular_function
GO:0016887ATPase activityIDAmolecular_function
GO:0030307Positive regulation of cell growthIMPbiological_process
GO:0031011Ino80 complexIDAcellular_component
GO:0032508DNA duplex unwindingIDAbiological_process
GO:0034644Cellular response to UVIMPbiological_process
GO:0043014Alpha-tubulin bindingIMPmolecular_function
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIMPbiological_process
GO:0051225Spindle assemblyIMPbiological_process
GO:0070914UV-damage excision repairIMPbiological_process
GO:0071479Cellular response to ionizing radiationIMPbiological_process
GO:2000045Regulation of G1/S transition of mitotic cell cycleIMPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.57051618480.34042785610.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0313545536
GSE13712_SHEARUp0.1318556125
GSE13712_STATICUp0.1656201868
GSE19018Down-0.1225914149
GSE19899_A1Down-0.2899929443
GSE19899_A2Up0.0884571671
PubMed_21979375_A1Down-0.4644259507
PubMed_21979375_A2Down-0.2155549890
GSE35957Down-0.2067230276
GSE36640Down-0.0409414165
GSE54402Down-0.0513010035
GSE9593Up0.2048611958
GSE43922Down-0.2595692162
GSE24585Down-0.2650287008
GSE37065Up0.0156278439
GSE28863_A1Up0.6918172076
GSE28863_A2Up0.7201325426
GSE28863_A3Down-0.1547736116
GSE28863_A4Up0.0534992742
GSE48662Down-0.0756061282

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

23979016The mINO80 chromatin remodeling complex is required for efficient telomere replication and maintenance of genome stability
23979016The INO80 (inositol requiring mutant 80) chromatin remodeling complex plays important roles in transcriptional regulation and DNA replication and repair, and consists of several functional protein subunits, including the critical Ino80 ATPase catalytic subunit
23979016While the function of INO80 has been studied in yeast and mammalian cell lines, we do not know how mIno80 contributes to the maintenance of genome stability to prevent cancer development in mice
23979016Here, we use a conditional knockout approach to explore the cellular and organismal functions of mIno80
23979016Deletion of mIno80 results in profound cellular proliferative defects and activation of p21-dependent cellular senescence
23979016While mIno80 is required for efficient repair of DNA double strand breaks, its depletion did not impact upon the formation of gamma-H2AX and 53BP1 DNA damage foci, or the activation of the ATM-CHK2-dependent DNA damage response
23979016In a p53(-/-) tumor-prone background, mIno80 haploinsufficiency favored the development of sarcomas
23979016Our studies suggest that the mIno80 chromatin remodeling complex plays important roles in telomere replication, HDR-mediated repair of dysfunctional telomeres, and maintenance of genome stability
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