HCSGD entry for POU4F2

1. General information

Official gene symbolPOU4F2
Entrez ID5458
Gene full namePOU class 4 homeobox 2
Other gene symbolsBRN3.2 BRN3B Brn-3b
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterISSbiological_process
GO:0000165MAPK cascadeIDAbiological_process
GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA bindingIDAmolecular_function
GO:0001077RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptionIDAmolecular_function
GO:0001078RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcriptionISSmolecular_function
GO:0003682Chromatin bindingIEAmolecular_function
GO:0005634NucleusIC ISScellular_component
GO:0006366Transcription from RNA polymerase II promoterIDA ISSbiological_process
GO:0007411Axon guidanceISSbiological_process
GO:0007605Sensory perception of soundIEAbiological_process
GO:0016607Nuclear speckIEAcellular_component
GO:0030182Neuron differentiationISSbiological_process
GO:0030520Intracellular estrogen receptor signaling pathwayIDAbiological_process
GO:0031290Retinal ganglion cell axon guidanceIEAbiological_process
GO:0045597Positive regulation of cell differentiationISSbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIDAbiological_process
GO:0048675Axon extensionIEAbiological_process
GO:0050885Neuromuscular process controlling balanceIEAbiological_process
GO:0060041Retina development in camera-type eyeISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.40872095670.87840484400.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0457218931
GSE13712_SHEARDown-0.0726285594
GSE13712_STATICUp0.0374361845
GSE19018Up0.2215890930
GSE19899_A1Up0.1837924717
GSE19899_A2Up0.4296148021
PubMed_21979375_A1Up0.2250803444
PubMed_21979375_A2Up0.0067249778
GSE35957Up0.1440099418
GSE36640Down-0.0327532931
GSE54402Down-0.0352994363
GSE9593Down-0.2105299139
GSE43922Up0.0246425687
GSE24585Down-0.0287921221
GSE37065Down-0.0666702945
GSE28863_A1Down-0.0908343112
GSE28863_A2Up0.1053951114
GSE28863_A3Up0.2628438966
GSE28863_A4Up0.0164583286
GSE48662Up0.0920564216

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-23a-3pMIMAT0000078MIRT003856Luciferase reporter assayFunctional MTI14697198
hsa-miR-23a-3pMIMAT0000078MIRT003856Flow//GFP reporter assay//Northern blot//qRT-PCR//Western blotFunctional MTI20609388
hsa-miR-214-3pMIMAT0000271MIRT005551Flow//GFP reporter assay//Northern blot//qRT-PCR//Western blotFunctional MTI20609388
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    • mirRecord

MicroRNA name

mirBase ID

Target site number

MiRNA mature ID

Test method inter

MiRNA regulation site

Reporter target site

Pubmed ID

hsa-miR-23a-3pMIMAT00000782hsa-miR-23a14697198
hsa-miR-23a-3pMIMAT00000784hsa-miR-23a14697198
hsa-miR-23a-3pMIMAT00000781hsa-miR-23a14697198
hsa-miR-23a-3pMIMAT00000783hsa-miR-23a14697198
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6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.