HCSGD entry for DLL4

1. General information

Official gene symbolDLL4
Entrez ID54567
Gene full namedelta-like 4 (Drosophila)
Other gene symbolshdelta2
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterISSbiological_process
GO:0001525AngiogenesisISSbiological_process
GO:0001569Patterning of blood vesselsISSbiological_process
GO:0001974Blood vessel remodelingISSbiological_process
GO:0003208Cardiac ventricle morphogenesisISSbiological_process
GO:0003209Cardiac atrium morphogenesisISSbiological_process
GO:0003222Ventricular trabecula myocardium morphogenesisISSbiological_process
GO:0003344Pericardium morphogenesisISSbiological_process
GO:0005112Notch bindingIEAmolecular_function
GO:0005509Calcium ion bindingIEAmolecular_function
GO:0005886Plasma membraneTAScellular_component
GO:0007165Signal transductionTASbiological_process
GO:0007219Notch signaling pathwayTASbiological_process
GO:0007220Notch receptor processingTASbiological_process
GO:0008015Blood circulationTASbiological_process
GO:0008285Negative regulation of cell proliferationIMPbiological_process
GO:0010596Negative regulation of endothelial cell migrationIMPbiological_process
GO:0016021Integral component of membraneIEAcellular_component
GO:0035912Dorsal aorta morphogenesisISSbiological_process
GO:0035924Cellular response to vascular endothelial growth factor stimulusIMPbiological_process
GO:0044344Cellular response to fibroblast growth factor stimulusIDAbiological_process
GO:0050767Regulation of neurogenesisIEAbiological_process
GO:0061314Notch signaling involved in heart developmentISSbiological_process
GO:0072554Blood vessel lumenizationIEAbiological_process
GO:0090051Negative regulation of cell migration involved in sprouting angiogenesisIMPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.95297044950.02594529840.99999024730.3087279385

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.2338342146
GSE13712_SHEARDown-0.1811594354
GSE13712_STATICDown-0.4424823801
GSE19018Down-0.2744260583
GSE19899_A1Down-0.5735790193
GSE19899_A2Down-0.5097963426
PubMed_21979375_A1Down-1.0755663563
PubMed_21979375_A2Down-0.3778240747
GSE35957Up0.1452787322
GSE36640Down-0.1721382994
GSE54402Down-0.1918585375
GSE9593Up0.2977231287
GSE43922Down-1.5432748370
GSE24585Up0.4798998482
GSE37065Down-0.1290106453
GSE28863_A1Down-0.2180067555
GSE28863_A2Down-0.0906550039
GSE28863_A3Up0.1229182911
GSE28863_A4Up0.0972744621
GSE48662Up0.0244266618

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.