HCSGD entry for DDIT4
1. General information
| Official gene symbol | DDIT4 |
|---|---|
| Entrez ID | 54541 |
| Gene full name | DNA-damage-inducible transcript 4 |
| Other gene symbols | Dig2 REDD-1 REDD1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001666 | Response to hypoxia | IDA | biological_process |
| GO:0001764 | Neuron migration | ISS | biological_process |
| GO:0005622 | Intracellular | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005739 | Mitochondrion | IEA | cellular_component |
| GO:0005829 | Cytosol | IEA | cellular_component |
| GO:0007420 | Brain development | ISS | biological_process |
| GO:0008283 | Cell proliferation | ISS | biological_process |
| GO:0010801 | Negative regulation of peptidyl-threonine phosphorylation | ISS | biological_process |
| GO:0030182 | Neuron differentiation | ISS | biological_process |
| GO:0032007 | Negative regulation of TOR signaling | IMP | biological_process |
| GO:0033137 | Negative regulation of peptidyl-serine phosphorylation | ISS | biological_process |
| GO:0042771 | Intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator | ISS | biological_process |
| GO:0043241 | Protein complex disassembly | IEA | biological_process |
| GO:0045820 | Negative regulation of glycolysis | IEA | biological_process |
| GO:0048011 | Neurotrophin TRK receptor signaling pathway | ISS | biological_process |
| GO:0051607 | Defense response to virus | IEA | biological_process |
| GO:0071889 | 14-3-3 protein binding | IEA | molecular_function |
| GO:0072593 | Reactive oxygen species metabolic process | IEA | biological_process |
| GO:1901216 | Positive regulation of neuron death | ISS | biological_process |
| GO:1902532 | Negative regulation of intracellular signal transduction | ISS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0787986171 | 0.0089267847 | 0.5909999715 | 0.1870715764 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.5172705587 |
| GSE13712_SHEAR | Down | -0.4979729756 |
| GSE13712_STATIC | Down | -0.3677994980 |
| GSE19018 | Up | 2.9068879785 |
| GSE19899_A1 | Up | 0.2658405298 |
| GSE19899_A2 | Down | -0.9909866906 |
| PubMed_21979375_A1 | Up | 0.0087257774 |
| PubMed_21979375_A2 | Down | -0.3998893363 |
| GSE35957 | Down | -1.6285648962 |
| GSE36640 | Down | -1.1937187274 |
| GSE54402 | Down | -0.6975915872 |
| GSE9593 | Down | -0.4906777410 |
| GSE43922 | Up | 0.9067213384 |
| GSE24585 | Up | 0.1403217976 |
| GSE37065 | Down | -0.5962776088 |
| GSE28863_A1 | Down | -0.1984496455 |
| GSE28863_A2 | Down | -0.3298025078 |
| GSE28863_A3 | Up | 0.3574625314 |
| GSE28863_A4 | Down | -0.0460679308 |
| GSE48662 | Up | 0.1290496855 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-221-3p | MIMAT0000278 | MIRT003358 | Luciferase reporter assay//Microarray//qRT-PCR//Western blot//Reporter assay;Western blot;qRT-PCR;Microarray;Other | Functional MTI | 20018759 |
| hsa-miR-221-3p | MIMAT0000278 | MIRT003358 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-181a-5p | MIMAT0000256 | MIRT005575 | Immunoblot//Luciferase reporter assay//qRT-PCR | Functional MTI | 21274007 |
| hsa-miR-124-3p | MIMAT0000422 | MIRT022661 | Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-101-3p | MIMAT0000099 | MIRT027381 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT040402 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-221-3p | MIMAT0000278 | 1 | hsa-miR-221 | {Western blot} | {overexpression by miRNA precursor transfection} | 20018759 | |
| hsa-miR-221-3p | MIMAT0000278 | 2 | hsa-miR-221 | {Western blot} | {overexpression by miRNA precursor transfection} | 20018759 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 22627671 | Overexpression of REDD1 (Regulated in DNA Damage Response and Development), a negative regulator of TORC1, delays the onset of replicative senescence |
| 20647331 | Coincident with these DNA damage markers, the level of p53 protein and genes transcriptionally activated by p53, such as p21, TP53INP1, and DDIT4, increased |
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