HCSGD entry for PON1
1. General information
| Official gene symbol | PON1 |
|---|---|
| Entrez ID | 5444 |
| Gene full name | paraoxonase 1 |
| Other gene symbols | ESA MVCD5 PON |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004063 | Aryldialkylphosphatase activity | IDA | molecular_function |
| GO:0004064 | Arylesterase activity | IDA IEA NAS | molecular_function |
| GO:0005509 | Calcium ion binding | IDA | molecular_function |
| GO:0005543 | Phospholipid binding | IDA | molecular_function |
| GO:0005576 | Extracellular region | IEA NAS | cellular_component |
| GO:0005615 | Extracellular space | IDA | cellular_component |
| GO:0009605 | Response to external stimulus | NAS | biological_process |
| GO:0009636 | Response to toxic substance | IEA | biological_process |
| GO:0010875 | Positive regulation of cholesterol efflux | IDA | biological_process |
| GO:0016311 | Dephosphorylation | IDA | biological_process |
| GO:0019439 | Aromatic compound catabolic process | IDA | biological_process |
| GO:0032411 | Positive regulation of transporter activity | IDA | biological_process |
| GO:0034364 | High-density lipoprotein particle | IDA TAS | cellular_component |
| GO:0034366 | Spherical high-density lipoprotein particle | IDA | cellular_component |
| GO:0034445 | Negative regulation of plasma lipoprotein particle oxidation | IDA | biological_process |
| GO:0042803 | Protein homodimerization activity | IDA | molecular_function |
| GO:0043231 | Intracellular membrane-bounded organelle | IEA | cellular_component |
| GO:0046395 | Carboxylic acid catabolic process | IDA | biological_process |
| GO:0046434 | Organophosphate catabolic process | IDA | biological_process |
| GO:0046470 | Phosphatidylcholine metabolic process | IDA | biological_process |
| GO:0051099 | Positive regulation of binding | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.8094537784 | 0.7851539911 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0110278231 |
| GSE13712_SHEAR | Down | -0.0595570090 |
| GSE13712_STATIC | Down | -0.0671620444 |
| GSE19018 | Down | -0.0167998961 |
| GSE19899_A1 | Up | 0.1416427711 |
| GSE19899_A2 | Up | 0.0861857668 |
| PubMed_21979375_A1 | Down | -0.0784759580 |
| PubMed_21979375_A2 | Up | 0.0740144166 |
| GSE35957 | Up | 0.0634238258 |
| GSE36640 | Up | 0.0040229522 |
| GSE54402 | Up | 0.0064635249 |
| GSE9593 | Down | -0.0813848388 |
| GSE43922 | Up | 0.0387099021 |
| GSE24585 | Up | 0.1271931753 |
| GSE37065 | Down | -0.1109988935 |
| GSE28863_A1 | Up | 0.0347095186 |
| GSE28863_A2 | Down | -0.0361672640 |
| GSE28863_A3 | Up | 0.0205316414 |
| GSE28863_A4 | Up | 0.0804821837 |
| GSE48662 | Down | -0.0930932557 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-616-3p | MIMAT0004805 | MIRT007325 | Luciferase reporter assay | Functional MTI | 23497787 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 3 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 22897574 | Knockdown of paraoxonase 1 expression influences the ageing of human dermal microvascular endothelial cells |
| 22897574 | Among identified proteins, paraoxonase 1 (PON1) was selected in this study |
| 22897574 | To elucidate the role of PON1 on skin ageing and determine how it controls cellular senescence, the characteristics of PON1 in human dermal microvascular endothelial cells (HDMECs) were determined |
| 22897574 | When the expression of endogenous PON1 was knocked-down by small interfering RNA (siRNA) targeting PON1, HDMECs showed characteristic features of cellular senescence such as increases in senescence-associated beta-galactosidase stained cells and enlarged and flattened cell morphology |
| 22897574 | At 48 h post-transfection, the protein expression of p16 in PON1 siRNA-treated HDMECs was higher than that in scrambled siRNA-treated HDMECs |
| 22897574 | In addition, the expressions of moesin and rho GTP dissociation inhibitor, additional age-related candidate biomarkers, were decreased by PON1 knock-down in HDMECs |
| 22897574 | In conclusion, these results suggest that PON1 functions as an ageing-related protein and plays an important role in the cellular senescence of HDMECs |
| 22814745 | Moreover, high-density lipoprotein and its associated enzyme paraoxonase-1 exerted unexpected roles in the detoxification of UCMVs |
| 21562236 | The expression of antioxidant defense genes, such as glutathione peroxidase-1, Cu/Zn superoxide dismutase (Sod1), paraoxonase enzymes (Pon1, Pon2, and Pon3), were significantly lower in the liver of HF/C pups than in C/C pups |
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