HCSGD entry for POMC
1. General information
| Official gene symbol | POMC |
|---|---|
| Entrez ID | 5443 |
| Gene full name | proopiomelanocortin |
| Other gene symbols | ACTH CLIP LPH MSH NPP POC |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001664 | G-protein coupled receptor binding | IDA | molecular_function |
| GO:0005102 | Receptor binding | IMP | molecular_function |
| GO:0005179 | Hormone activity | IEA IMP ISS | molecular_function |
| GO:0005576 | Extracellular region | IEA TAS | cellular_component |
| GO:0005615 | Extracellular space | IDA | cellular_component |
| GO:0005737 | Cytoplasm | ISS | cellular_component |
| GO:0005777 | Peroxisome | IDA | cellular_component |
| GO:0005782 | Peroxisomal matrix | IDA | cellular_component |
| GO:0006091 | Generation of precursor metabolites and energy | IMP | biological_process |
| GO:0007165 | Signal transduction | IMP | biological_process |
| GO:0007218 | Neuropeptide signaling pathway | IEA | biological_process |
| GO:0007267 | Cell-cell signaling | IMP | biological_process |
| GO:0008217 | Regulation of blood pressure | IEA ISS | biological_process |
| GO:0016486 | Peptide hormone processing | TAS | biological_process |
| GO:0030141 | Secretory granule | IEA ISS | cellular_component |
| GO:0031781 | Type 3 melanocortin receptor binding | IPI | molecular_function |
| GO:0031782 | Type 4 melanocortin receptor binding | IPI | molecular_function |
| GO:0032098 | Regulation of appetite | IMP | biological_process |
| GO:0032720 | Negative regulation of tumor necrosis factor production | IDA | biological_process |
| GO:0033059 | Cellular pigmentation | IMP | biological_process |
| GO:0034774 | Secretory granule lumen | TAS | cellular_component |
| GO:0044267 | Cellular protein metabolic process | TAS | biological_process |
| GO:0045944 | Positive regulation of transcription from RNA polymerase II promoter | IDA | biological_process |
| GO:0070996 | Type 1 melanocortin receptor binding | IDA IPI | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.3708954789 | 0.5234771285 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0067747055 |
| GSE13712_SHEAR | Down | -0.7028590269 |
| GSE13712_STATIC | Down | -0.3553396976 |
| GSE19018 | Up | 0.2450195184 |
| GSE19899_A1 | Up | 0.0267902704 |
| GSE19899_A2 | Up | 0.2601725693 |
| PubMed_21979375_A1 | Up | 0.2827076049 |
| PubMed_21979375_A2 | Down | -0.0895980177 |
| GSE35957 | Up | 0.0883872594 |
| GSE36640 | Down | -0.0605790434 |
| GSE54402 | Up | 0.0536810382 |
| GSE9593 | Up | 0.1375827941 |
| GSE43922 | Up | 0.1285354321 |
| GSE24585 | Up | 0.2004978369 |
| GSE37065 | Down | -0.1729159881 |
| GSE28863_A1 | Down | -0.2023709947 |
| GSE28863_A2 | Down | -0.1776995346 |
| GSE28863_A3 | Up | 0.5609322127 |
| GSE28863_A4 | Up | 0.0594234880 |
| GSE48662 | Down | -0.0071586649 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-488-3p | MIMAT0004763 | MIRT005899 | Luciferase reporter assay//Microarray | Functional MTI | 21168126 |
| hsa-miR-335-5p | MIMAT0000765 | MIRT017417 | Microarray | Functional MTI (Weak) | 18185580 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 8 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 27164758 | Proof of concept (POC) of photoreceptor transplantation in mouse is close to being accomplished using iPS cell-derived photoreceptor cells |
| 25798129 | Adrenocortical cell differentiation, renewal, and function are regulated by a variety of endocrine/paracrine factors including adrenocorticotropin, angiotensin II, insulin-related growth hormones, luteinizing hormone, activin, and inhibin |
| 25622010 | 7) years a subsample of them took part in the Trier Social Stress Test (TSST) during which salivary cortisol (n=283) and plasma cortisol and ACTH concentrations (n=215) were measured |
| 25622010 | Only one non-linear association between LTL and plasma ACTH area under the curve increment was significant after adjustments for covariates and confounders |
| 21536883 | Cushing disease caused by adrenocorticotropin (ACTH)-secreting pituitary adenomas leads to hypercortisolemia predisposing to diabetes, hypertension, osteoporosis, central obesity, cardiovascular morbidity, and increased mortality |
| 21536883 | Here, we generated germline transgenic zebrafish with overexpression of pituitary tumor transforming gene (PTTG/securin) targeted to the adenohypophyseal proopiomelanocortin (POMC) lineage, which recapitulated early features pathognomonic of corticotroph adenomas, including corticotroph expansion and partial glucocorticoid resistance |
| 21536883 | We further validated that orally administered R-roscovitine suppresses ACTH and corticosterone levels, and also restrained tumor growth in a mouse model of ACTH-secreting pituitary adenomas |
| 10911949 | Recent work has demonstrated that alpha-melanocyte stimulating hormone (alpha-MSH) or cholera toxin (CT) can activate a cAMP pathway that elicits proliferative arrest and senescence in normal human pigmented melanocytes |
| 9048642 | ACTH treatment of adrenocortical cells specifically induced a 2 |
| 9048642 | Laminin, which is synthesized under the control of the systemic hormone ACTH, appears as a permissive factor that facilitates proper homeostasis of the adrenocortical tissue |
| 3032889 | All five clonal cell lines had stimulated steroid production with 8-bromo-cAMP, but only four of the clonal lines were stimulated also by adrenocorticotropin |
| 3023404 | Clonal variation in response to adrenocorticotropin in cultured bovine adrenocortical cells: relationship to senescence |
| 3023404 | During cellular senescence, non-clonal cultures of bovine adrenocortical cells show a continuous decline in the rate of production of cyclic AMP (cAMP) stimulated by adrenocorticotropin (ACTH), without changes in the rate of forskolin- or prostaglandin E1-stimulated cAMP production |
| 3023404 | We investigated the possible mechanisms for loss of response to ACTH by examining the properties of clones of bovine adrenocortical cells |
| 3023404 | The results show that cloning is not necessarily associated with a loss of response to ACTH, but that clones with high ACTH response can give rise to subclones with low response |
| 3023404 | Clones of adrenocortical cells, at the same approximate population doubling level (PDL), showed ACTH response levels that ranged from 12 to 135 pmol cAMP/10(6) cells/min, whereas mass cultures at this PDL showed approximately 50 pmol/10(6) cells/min |
| 3023404 | The replicative potential of clones varied widely, and there was no apparent correlation between ACTH response levels and growth potential |
| 3023404 | The level of ACTH response in each clone was stable during proliferation through at least 25 PD beyond the stage at which the clone was isolated |
| 3023404 | When clones were subcloned, a clone with a high ACTH response level produced sister subclones that had ACTH response levels ranging from 3% of that of the parent clone to a level slightly greater than that of the parent clone |
| 3023404 | The growth potential of sister subclones varied widely, as for the parent clones, and there was no obvious correlation between growth potential and ACTH response |
| 3023404 | The loss of ACTH response and the loss of proliferative potential appear to be independent stochastic events |
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