HCSGD entry for POLR2A
1. General information
| Official gene symbol | POLR2A |
|---|---|
| Entrez ID | 5430 |
| Gene full name | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa |
| Other gene symbols | POLR2 POLRA RPB1 RPBh1 RPO2 RPOL2 RpIILS hRPB220 hsRPB1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000398 | MRNA splicing, via spliceosome | TAS | biological_process |
| GO:0001055 | RNA polymerase II activity | IBA | molecular_function |
| GO:0003677 | DNA binding | IEA NAS | molecular_function |
| GO:0003899 | DNA-directed RNA polymerase activity | IEA NAS | molecular_function |
| GO:0003968 | RNA-directed RNA polymerase activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA NAS | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0005665 | DNA-directed RNA polymerase II, core complex | IDA | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0006281 | DNA repair | TAS | biological_process |
| GO:0006283 | Transcription-coupled nucleotide-excision repair | TAS | biological_process |
| GO:0006289 | Nucleotide-excision repair | TAS | biological_process |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0006355 | Regulation of transcription, DNA-templated | NAS | biological_process |
| GO:0006366 | Transcription from RNA polymerase II promoter | IDA NAS TAS | biological_process |
| GO:0006367 | Transcription initiation from RNA polymerase II promoter | TAS | biological_process |
| GO:0006368 | Transcription elongation from RNA polymerase II promoter | TAS | biological_process |
| GO:0006370 | 7-methylguanosine mRNA capping | TAS | biological_process |
| GO:0008380 | RNA splicing | TAS | biological_process |
| GO:0010467 | Gene expression | TAS | biological_process |
| GO:0016032 | Viral process | TAS | biological_process |
| GO:0031625 | Ubiquitin protein ligase binding | IPI | molecular_function |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
| GO:0050434 | Positive regulation of viral transcription | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0344050188 | 0.9665142776 | 0.4258649741 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0528634754 |
| GSE13712_SHEAR | Up | 0.1537110014 |
| GSE13712_STATIC | Down | -0.0793215589 |
| GSE19018 | Up | 0.0406935916 |
| GSE19899_A1 | Up | 0.0210543905 |
| GSE19899_A2 | Up | 0.0632311167 |
| PubMed_21979375_A1 | Up | 0.5016537511 |
| PubMed_21979375_A2 | Up | 0.3033911652 |
| GSE35957 | Up | 0.0416557764 |
| GSE36640 | Down | -0.0691821210 |
| GSE54402 | Up | 0.0175738366 |
| GSE9593 | Down | -0.0828181932 |
| GSE43922 | Up | 0.1869923625 |
| GSE24585 | Up | 0.8355190145 |
| GSE37065 | Up | 0.0349247896 |
| GSE28863_A1 | Up | 1.3934390847 |
| GSE28863_A2 | Up | 0.8683536977 |
| GSE28863_A3 | Down | -0.1008426675 |
| GSE28863_A4 | Up | 0.0335858319 |
| GSE48662 | Up | 0.0953973057 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-34a-5p | MIMAT0000255 | MIRT025433 | Proteomics | Functional MTI (Weak) | 21566225 |
| hsa-miR-744-5p | MIMAT0004945 | MIRT037520 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-454-3p | MIMAT0003885 | MIRT039231 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-652-3p | MIMAT0003322 | MIRT039557 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT039757 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-484 | MIMAT0002174 | MIRT042066 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-324-5p | MIMAT0000761 | MIRT043145 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-320a | MIMAT0000510 | MIRT044694 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-10b-5p | MIMAT0000254 | MIRT047400 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-10a-5p | MIMAT0000253 | MIRT047510 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-93-5p | MIMAT0000093 | MIRT048740 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-17-3p | MIMAT0000071 | MIRT050740 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT051264 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7b-5p | MIMAT0000063 | MIRT051921 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-1260b | MIMAT0015041 | MIRT052702 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
