HCSGD entry for POLE

1. General information

Official gene symbolPOLE
Entrez ID5426
Gene full namepolymerase (DNA directed), epsilon, catalytic subunit
Other gene symbolsCRCS12 FILS POLE1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000082G1/S transition of mitotic cell cycleIMP TASbiological_process
GO:0000166Nucleotide bindingIEAmolecular_function
GO:0000278Mitotic cell cycleTASbiological_process
GO:0000722Telomere maintenance via recombinationTASbiological_process
GO:0000723Telomere maintenanceTASbiological_process
GO:0000731DNA synthesis involved in DNA repairIMPbiological_process
GO:0001701In utero embryonic developmentIEAbiological_process
GO:0003676Nucleic acid bindingIEAmolecular_function
GO:0003677DNA bindingIDA IEAmolecular_function
GO:0003682Chromatin bindingIDAmolecular_function
GO:0003887DNA-directed DNA polymerase activityIEA IMPmolecular_function
GO:0005634NucleusIDA IEAcellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0006260DNA replicationIMPbiological_process
GO:0006270DNA replication initiationTASbiological_process
GO:0006281DNA repairTASbiological_process
GO:0006283Transcription-coupled nucleotide-excision repairTASbiological_process
GO:0006287Base-excision repair, gap-fillingIDAbiological_process
GO:0006289Nucleotide-excision repairTASbiological_process
GO:0006297Nucleotide-excision repair, DNA gap fillingIMP TASbiological_process
GO:0008270Zinc ion bindingIEAmolecular_function
GO:0008622Epsilon DNA polymerase complexIDAcellular_component
GO:0032201Telomere maintenance via semi-conservative replicationTASbiological_process
GO:00515394 iron, 4 sulfur cluster bindingIEAmolecular_function
GO:0071897DNA biosynthetic processIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.60179534970.06721856690.99999024730.4891512027

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0365591630
GSE13712_SHEARDown-0.6434054007
GSE13712_STATICDown-0.3882132471
GSE19018Up0.0940695242
GSE19899_A1Down-0.1644609533
GSE19899_A2Down-0.7807812368
PubMed_21979375_A1Down-0.1261182151
PubMed_21979375_A2Down-0.1813881616
GSE35957Down-0.5211345612
GSE36640Down-1.1446846302
GSE54402Up0.1130737471
GSE9593Down-0.5332999436
GSE43922Down-0.0826626444
GSE24585Up0.3826056052
GSE37065Down-0.2597696489
GSE28863_A1Up0.4614408539
GSE28863_A2Up0.4112471001
GSE28863_A3Up0.3457803184
GSE28863_A4Up0.1295445878
GSE48662Down-0.1802425308

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-193b-3pMIMAT0002819MIRT016490MicroarrayFunctional MTI (Weak)20304954
hsa-miR-324-5pMIMAT0000761MIRT043193CLASHFunctional MTI (Weak)23622248
hsa-miR-222-3pMIMAT0000279MIRT046796CLASHFunctional MTI (Weak)23622248
hsa-miR-93-5pMIMAT0000093MIRT048792CLASHFunctional MTI (Weak)23622248
hsa-miR-92a-3pMIMAT0000092MIRT048946CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.