HCSGD entry for POLD1
1. General information
| Official gene symbol | POLD1 |
|---|---|
| Entrez ID | 5424 |
| Gene full name | polymerase (DNA directed), delta 1, catalytic subunit |
| Other gene symbols | CDC2 CRCS10 POLD |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000109 | Nucleotide-excision repair complex | IDA | cellular_component |
| GO:0000166 | Nucleotide binding | IEA | molecular_function |
| GO:0000278 | Mitotic cell cycle | TAS | biological_process |
| GO:0000722 | Telomere maintenance via recombination | TAS | biological_process |
| GO:0000723 | Telomere maintenance | TAS | biological_process |
| GO:0000731 | DNA synthesis involved in DNA repair | IDA IMP | biological_process |
| GO:0003676 | Nucleic acid binding | IEA | molecular_function |
| GO:0003677 | DNA binding | IDA IEA | molecular_function |
| GO:0003682 | Chromatin binding | IDA | molecular_function |
| GO:0003887 | DNA-directed DNA polymerase activity | IEA IMP | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0006260 | DNA replication | IMP | biological_process |
| GO:0006271 | DNA strand elongation involved in DNA replication | TAS | biological_process |
| GO:0006281 | DNA repair | TAS | biological_process |
| GO:0006283 | Transcription-coupled nucleotide-excision repair | TAS | biological_process |
| GO:0006284 | Base-excision repair | TAS | biological_process |
| GO:0006287 | Base-excision repair, gap-filling | IDA IEA | biological_process |
| GO:0006289 | Nucleotide-excision repair | TAS | biological_process |
| GO:0006297 | Nucleotide-excision repair, DNA gap filling | IC IMP TAS | biological_process |
| GO:0007346 | Regulation of mitotic cell cycle | IBA | biological_process |
| GO:0008408 | 3'-5' exonuclease activity | IBA IEA | molecular_function |
| GO:0009411 | Response to UV | TAS | biological_process |
| GO:0019985 | Translesion synthesis | IBA | biological_process |
| GO:0032201 | Telomere maintenance via semi-conservative replication | TAS | biological_process |
| GO:0043137 | DNA replication, removal of RNA primer | IBA | biological_process |
| GO:0043625 | Delta DNA polymerase complex | IBA | cellular_component |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0045004 | DNA replication proofreading | IBA IEA | biological_process |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
| GO:0051539 | 4 iron, 4 sulfur cluster binding | IEA | molecular_function |
| GO:0055089 | Fatty acid homeostasis | IMP | biological_process |
| GO:0090305 | Nucleic acid phosphodiester bond hydrolysis | IBA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.7747303332 | 0.0272392652 | 0.9999902473 | 0.3144582018 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.3983045426 |
| GSE13712_SHEAR | Down | -0.5676725131 |
| GSE13712_STATIC | Down | -0.1989613096 |
| GSE19018 | Up | 0.3734739571 |
| GSE19899_A1 | Down | -0.2934225904 |
| GSE19899_A2 | Down | -1.5605603901 |
| PubMed_21979375_A1 | Up | 0.0340056881 |
| PubMed_21979375_A2 | Up | 0.2573900222 |
| GSE35957 | Down | -0.8661905513 |
| GSE36640 | Down | -0.5997672582 |
| GSE54402 | Down | -0.0198489202 |
| GSE9593 | Down | -1.2447159712 |
| GSE43922 | Up | 0.0520172627 |
| GSE24585 | Down | -0.1491757453 |
| GSE37065 | Down | -0.0175296032 |
| GSE28863_A1 | Down | -0.0418544714 |
| GSE28863_A2 | Up | 0.1287505064 |
| GSE28863_A3 | Up | 0.3588472126 |
| GSE28863_A4 | Up | 0.0786970458 |
| GSE48662 | Down | -0.6505274629 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-24-3p | MIMAT0000080 | MIRT004837 | Luciferase reporter assay//Microarray//qRT-PCR//Western blot | Functional MTI | 19748357 |
| hsa-miR-193b-3p | MIMAT0002819 | MIRT016440 | Microarray | Functional MTI (Weak) | 20304954 |
| hsa-miR-1 | MIMAT0000416 | MIRT023874 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-34a-5p | MIMAT0000255 | MIRT025336 | Proteomics | Functional MTI (Weak) | 21566225 |
| hsa-miR-324-5p | MIMAT0000761 | MIRT043208 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7e-5p | MIMAT0000066 | MIRT051665 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-24-3p | MIMAT0000080 | 1 | hsa-miR-24 | 19748357 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
