HCSGD entry for TREM1
1. General information
| Official gene symbol | TREM1 |
|---|---|
| Entrez ID | 54210 |
| Gene full name | triggering receptor expressed on myeloid cells 1 |
| Other gene symbols | CD354 TREM-1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004872 | Receptor activity | TAS | molecular_function |
| GO:0005576 | Extracellular region | IEA | cellular_component |
| GO:0005886 | Plasma membrane | TAS | cellular_component |
| GO:0006959 | Humoral immune response | TAS | biological_process |
| GO:0007596 | Blood coagulation | TAS | biological_process |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0035556 | Intracellular signal transduction | TAS | biological_process |
| GO:0045087 | Innate immune response | TAS | biological_process |
| GO:0050900 | Leukocyte migration | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0001806694 | 0.9587454808 | 0.0393008264 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 1.1443856170 |
| GSE13712_SHEAR | Up | 0.0173759734 |
| GSE13712_STATIC | Up | 0.0574733135 |
| GSE19018 | Up | 0.0702150820 |
| GSE19899_A1 | Up | 0.8886091930 |
| GSE19899_A2 | Up | 4.0876651197 |
| PubMed_21979375_A1 | Up | 1.0945128728 |
| PubMed_21979375_A2 | Up | 4.3140452675 |
| GSE35957 | Down | -0.2988545081 |
| GSE36640 | Up | 0.6205597384 |
| GSE54402 | Up | 2.6775769648 |
| GSE9593 | Up | 1.6227426508 |
| GSE43922 | Up | 2.1640626974 |
| GSE24585 | Down | -0.0476932598 |
| GSE37065 | Up | 0.9889099069 |
| GSE28863_A1 | Up | 0.2600101611 |
| GSE28863_A2 | Down | -0.0184566871 |
| GSE28863_A3 | Up | 0.0077531884 |
| GSE28863_A4 | Down | -0.0378654240 |
| GSE48662 | Up | 0.1934648808 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| D-tartaric acid | DB01694 | EXPT03007 |
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirTarBase
- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 21877936 | The high fluorescence intensity of CD11b,c, and TREM-1 in the congenital asplenia may indicate a potentially elevated pro-inflammatory status of granulocytes, possibly due to the low activity of vagus nerve and spleen-dependent cholinergic anti-inflammatory pathway |
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