HCSGD entry for POLE3
1. General information
| Official gene symbol | POLE3 |
|---|---|
| Entrez ID | 54107 |
| Gene full name | polymerase (DNA directed), epsilon 3, accessory subunit |
| Other gene symbols | CHARAC17 CHRAC17 YBL1 p17 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003887 | DNA-directed DNA polymerase activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | TAS | cellular_component |
| GO:0005671 | Ada2/Gcn5/Ada3 transcription activator complex | IDA | cellular_component |
| GO:0006260 | DNA replication | TAS | biological_process |
| GO:0006261 | DNA-dependent DNA replication | TAS | biological_process |
| GO:0008622 | Epsilon DNA polymerase complex | IDA | cellular_component |
| GO:0043565 | Sequence-specific DNA binding | IEA | molecular_function |
| GO:0043966 | Histone H3 acetylation | IDA | biological_process |
| GO:0046982 | Protein heterodimerization activity | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1130850500 | 0.2330592607 | 0.6923730170 | 0.9301520546 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0334859800 |
| GSE13712_SHEAR | Up | 0.0923883579 |
| GSE13712_STATIC | Up | 0.1701391467 |
| GSE19018 | Down | -0.4871491591 |
| GSE19899_A1 | Up | 0.1242808241 |
| GSE19899_A2 | Down | -0.0722930655 |
| PubMed_21979375_A1 | Up | 1.1181305397 |
| PubMed_21979375_A2 | Down | -0.2037691266 |
| GSE35957 | Down | -0.1529762374 |
| GSE36640 | Down | -1.1600861295 |
| GSE54402 | Up | 0.5874816610 |
| GSE9593 | Down | -0.4007877380 |
| GSE43922 | Up | 0.3435659690 |
| GSE24585 | Down | -0.3173783297 |
| GSE37065 | Down | -0.1334744465 |
| GSE28863_A1 | Up | 0.3527438072 |
| GSE28863_A2 | Down | -0.0308877402 |
| GSE28863_A3 | Up | 0.6408007522 |
| GSE28863_A4 | Up | 0.2042130451 |
| GSE48662 | Down | -0.5107489777 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-155-5p | MIMAT0000646 | MIRT001521 | pSILAC//Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-155-5p | MIMAT0000646 | MIRT001521 | Reporter assay;Other | Non-Functional MTI | 20584899 |
| hsa-miR-7-5p | MIMAT0000252 | MIRT025939 | Microarray | Functional MTI (Weak) | 19073608 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT030344 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-18a-3p | MIMAT0002891 | MIRT040860 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
