HCSGD entry for ATP7B
1. General information
| Official gene symbol | ATP7B |
|---|---|
| Entrez ID | 540 |
| Gene full name | ATPase, Cu++ transporting, beta polypeptide |
| Other gene symbols | PWD WC1 WD WND |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000139 | Golgi membrane | TAS | cellular_component |
| GO:0000166 | Nucleotide binding | IEA | molecular_function |
| GO:0004008 | Copper-exporting ATPase activity | NAS TAS | molecular_function |
| GO:0005507 | Copper ion binding | IDA IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IDA IEA | molecular_function |
| GO:0005739 | Mitochondrion | IEA | cellular_component |
| GO:0005770 | Late endosome | IDA | cellular_component |
| GO:0005802 | Trans-Golgi network | IDA | cellular_component |
| GO:0005887 | Integral component of plasma membrane | TAS | cellular_component |
| GO:0006200 | ATP catabolic process | NAS TAS | biological_process |
| GO:0006825 | Copper ion transport | IEA IGI | biological_process |
| GO:0006878 | Cellular copper ion homeostasis | TAS | biological_process |
| GO:0006882 | Cellular zinc ion homeostasis | IEA | biological_process |
| GO:0007595 | Lactation | IEA | biological_process |
| GO:0008152 | Metabolic process | NAS TAS | biological_process |
| GO:0015677 | Copper ion import | IDA | biological_process |
| GO:0015680 | Intracellular copper ion transport | IEA | biological_process |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0016023 | Cytoplasmic membrane-bounded vesicle | IDA | cellular_component |
| GO:0016323 | Basolateral plasma membrane | IDA | cellular_component |
| GO:0019829 | Cation-transporting ATPase activity | IEA | molecular_function |
| GO:0034220 | Ion transmembrane transport | TAS | biological_process |
| GO:0046688 | Response to copper ion | IDA | biological_process |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
| GO:0048471 | Perinuclear region of cytoplasm | IDA | cellular_component |
| GO:0051208 | Sequestering of calcium ion | IDA | biological_process |
| GO:0055085 | Transmembrane transport | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1703290528 | 0.2412315793 | 0.8121795290 | 0.9457039619 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.2863772561 |
| GSE13712_SHEAR | Up | 0.0497798165 |
| GSE13712_STATIC | Down | -0.3372958279 |
| GSE19018 | Up | 1.4313914281 |
| GSE19899_A1 | Up | 0.1131379450 |
| GSE19899_A2 | Down | -0.3634075288 |
| PubMed_21979375_A1 | Down | -0.0758712559 |
| PubMed_21979375_A2 | Up | 0.3280460687 |
| GSE35957 | Down | -0.4820627716 |
| GSE36640 | Up | 1.0254184791 |
| GSE54402 | Down | -0.2967970402 |
| GSE9593 | Up | 0.0930185481 |
| GSE43922 | Up | 0.0344625945 |
| GSE24585 | Down | -0.1681944084 |
| GSE37065 | Down | -0.2985632021 |
| GSE28863_A1 | Up | 0.0900881363 |
| GSE28863_A2 | Down | -0.0562602705 |
| GSE28863_A3 | Up | 0.1400718935 |
| GSE28863_A4 | Up | 0.0546561460 |
| GSE48662 | Down | -0.0622893435 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-98-5p | MIMAT0000096 | MIRT027481 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT029106 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-616-5p | MIMAT0003284 | MIRT039602 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT039780 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-27b-3p | MIMAT0000419 | MIRT046229 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-222-3p | MIMAT0000279 | MIRT046616 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-27a-3p | MIMAT0000084 | MIRT050033 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-26a-5p | MIMAT0000082 | MIRT050131 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 27363602 | B10Sn-H2(b) /J, PWD |
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