HCSGD entry for EXOSC9

1. General information

Official gene symbolEXOSC9
Entrez ID5393
Gene full nameexosome component 9
Other gene symbolsPM/Scl-75 PMSCL1 RRP45 Rrp45p p5 p6
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:00001753'-5'-exoribonuclease activityNASmolecular_function
GO:0000176Nuclear exosome (RNase complex)IDA NAScellular_component
GO:0000178Exosome (RNase complex)IDAcellular_component
GO:0000288Nuclear-transcribed mRNA catabolic process, deadenylation-dependent decayTASbiological_process
GO:0000956Nuclear-transcribed mRNA catabolic processIMPbiological_process
GO:0003723RNA bindingNASmolecular_function
GO:0004532Exoribonuclease activityIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005730NucleolusIDA IEAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005829CytosolTAScellular_component
GO:0006364RRNA processingNASbiological_process
GO:0006955Immune responseNASbiological_process
GO:0010467Gene expressionTASbiological_process
GO:0016070RNA metabolic processTASbiological_process
GO:0016071MRNA metabolic processTASbiological_process
GO:0017091AU-rich element bindingIDAmolecular_function
GO:0030307Positive regulation of cell growthIMPbiological_process
GO:0043928Exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decayIMP TASbiological_process
GO:0071028Nuclear mRNA surveillanceIMPbiological_process
GO:0071035Nuclear polyadenylation-dependent rRNA catabolic processIMPbiological_process
GO:0090305Nucleic acid phosphodiester bond hydrolysisNASbiological_process
GO:0090501RNA phosphodiester bond hydrolysisNASbiological_process
GO:0090503RNA phosphodiester bond hydrolysis, exonucleolyticNASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.99785297670.00029407700.99999024730.0314650407

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.3459991372
GSE13712_SHEARDown-0.2401659475
GSE13712_STATICUp0.8271042534
GSE19018Down-1.0917158564
GSE19899_A1Down-0.9761423184
GSE19899_A2Down-1.7467033831
PubMed_21979375_A1Down-1.2218646334
PubMed_21979375_A2Down-1.6352251478
GSE35957Down-0.7845263563
GSE36640Down-1.8765689334
GSE54402Down-0.6239170319
GSE9593Down-1.3288959367
GSE43922Down-0.7159538295
GSE24585Down-0.1183294465
GSE37065Down-0.1274086609
GSE28863_A1Down-0.1760495580
GSE28863_A2Down-0.5008609699
GSE28863_A3Up0.0257003475
GSE28863_A4Down-0.2296722024
GSE48662Down-0.9322380113

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.