HCSGD entry for MBD3
1. General information
| Official gene symbol | MBD3 |
|---|---|
| Entrez ID | 53615 |
| Gene full name | methyl-CpG binding domain protein 3 |
| Other gene symbols | |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000122 | Negative regulation of transcription from RNA polymerase II promoter | IEA | biological_process |
| GO:0000792 | Heterochromatin | IEA | cellular_component |
| GO:0001701 | In utero embryonic development | IEA | biological_process |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0003682 | Chromatin binding | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005737 | Cytoplasm | IEA | cellular_component |
| GO:0006346 | Methylation-dependent chromatin silencing | IEA | biological_process |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0009888 | Tissue development | IEA | biological_process |
| GO:0016573 | Histone acetylation | IEA | biological_process |
| GO:0016581 | NuRD complex | IEA NAS | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.8668295961 | 0.3054169067 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0278457967 |
| GSE13712_SHEAR | Down | -0.1100064143 |
| GSE13712_STATIC | Down | -0.3987395575 |
| GSE19018 | Down | -0.3820521104 |
| GSE19899_A1 | Down | -0.1688690913 |
| GSE19899_A2 | Down | -0.3087133219 |
| PubMed_21979375_A1 | Up | 0.1119937375 |
| PubMed_21979375_A2 | Up | 0.3422834629 |
| GSE35957 | Up | 0.0039740859 |
| GSE36640 | Down | -0.3863919190 |
| GSE54402 | Up | 0.0112689056 |
| GSE9593 | Down | -0.2474051912 |
| GSE43922 | - | - |
| GSE24585 | - | - |
| GSE37065 | - | - |
| GSE28863_A1 | Down | -0.0114217547 |
| GSE28863_A2 | Down | -0.0428954545 |
| GSE28863_A3 | Up | 0.4153508850 |
| GSE28863_A4 | Up | 0.0678754947 |
| GSE48662 | Up | 0.2406012509 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-124-3p | MIMAT0000422 | MIRT022788 | Proteomics;Microarray | Non-Functional MTI (Weak) | 18668037 |
| hsa-miR-877-3p | MIMAT0004950 | MIRT037081 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
