HCSGD entry for PLOD1
1. General information
| Official gene symbol | PLOD1 |
|---|---|
| Entrez ID | 5351 |
| Gene full name | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 |
| Other gene symbols | EDS6 LH LH1 LLH PLOD |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001666 | Response to hypoxia | IEP | biological_process |
| GO:0005506 | Iron ion binding | IEA | molecular_function |
| GO:0005581 | Collagen | IEA | cellular_component |
| GO:0005783 | Endoplasmic reticulum | IEA | cellular_component |
| GO:0005789 | Endoplasmic reticulum membrane | TAS | cellular_component |
| GO:0006464 | Cellular protein modification process | NAS | biological_process |
| GO:0008475 | Procollagen-lysine 5-dioxygenase activity | IEA | molecular_function |
| GO:0008544 | Epidermis development | IMP TAS | biological_process |
| GO:0030198 | Extracellular matrix organization | TAS | biological_process |
| GO:0030867 | Rough endoplasmic reticulum membrane | IEA | cellular_component |
| GO:0031418 | L-ascorbic acid binding | IEA | molecular_function |
| GO:0042803 | Protein homodimerization activity | TAS | molecular_function |
| GO:0046947 | Hydroxylysine biosynthetic process | TAS | biological_process |
| GO:0055114 | Oxidation-reduction process | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0155597812 | 0.4376290870 | 0.3095741692 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.3330463735 |
| GSE13712_SHEAR | Down | -0.0335592845 |
| GSE13712_STATIC | Down | -0.0919763473 |
| GSE19018 | Up | 1.6720064745 |
| GSE19899_A1 | Up | 0.8129481241 |
| GSE19899_A2 | Up | 0.7258299558 |
| PubMed_21979375_A1 | Up | 0.6817502245 |
| PubMed_21979375_A2 | Up | 0.5757269184 |
| GSE35957 | Down | -0.6483589458 |
| GSE36640 | Up | 0.0778482282 |
| GSE54402 | Down | -0.2379741118 |
| GSE9593 | Up | 0.3508680803 |
| GSE43922 | Up | 0.2759216593 |
| GSE24585 | Down | -0.2375508681 |
| GSE37065 | Down | -0.0206573166 |
| GSE28863_A1 | Up | 0.1325349045 |
| GSE28863_A2 | Up | 0.6211548394 |
| GSE28863_A3 | Down | -0.2720491447 |
| GSE28863_A4 | Down | -0.3661161122 |
| GSE48662 | Up | 0.9855896767 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Vitamin C | DB00126 | NUTR00001 | APRD00084 | EXPT00568 | DB09541 |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-124-3p | MIMAT0000422 | MIRT022239 | Proteomics;Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-215-5p | MIMAT0000272 | MIRT024504 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-192-5p | MIMAT0000222 | MIRT026202 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-484 | MIMAT0002174 | MIRT041701 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-149-5p | MIMAT0000450 | MIRT045528 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-23b-3p | MIMAT0000418 | MIRT046301 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7a-5p | MIMAT0000062 | MIRT052618 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
