HCSGD entry for PLEK

1. General information

Official gene symbolPLEK
Entrez ID5341
Gene full namepleckstrin
Other gene symbolsP47
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0002244Hematopoietic progenitor cell differentiationIEPbiological_process
GO:0002576Platelet degranulationIEP TASbiological_process
GO:0005080Protein kinase C bindingIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005576Extracellular regionTAScellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005829CytosolTAScellular_component
GO:0006904Vesicle docking involved in exocytosisISSbiological_process
GO:0007229Integrin-mediated signaling pathwayIDAbiological_process
GO:0007596Blood coagulationTASbiological_process
GO:0010572Positive regulation of platelet activationISSbiological_process
GO:0010920Negative regulation of inositol phosphate biosynthetic processIDAbiological_process
GO:0010925Positive regulation of inositol-polyphosphate 5-phosphatase activityIDAbiological_process
GO:0030030Cell projection organizationIDAbiological_process
GO:0030168Platelet activationTASbiological_process
GO:0030836Positive regulation of actin filament depolymerizationIDAbiological_process
GO:0030845Phospholipase C-inhibiting G-protein coupled receptor signaling pathwayIDAbiological_process
GO:0030866Cortical actin cytoskeleton organizationIDAbiological_process
GO:0031529Ruffle organizationIDAbiological_process
GO:0031532Actin cytoskeleton reorganizationIDAbiological_process
GO:0032233Positive regulation of actin filament bundle assemblyIDAbiological_process
GO:0032587Ruffle membraneIDAcellular_component
GO:0033625Positive regulation of integrin activationISSbiological_process
GO:0042803Protein homodimerization activityIDAmolecular_function
GO:0043325Phosphatidylinositol-3,4-bisphosphate bindingIDAmolecular_function
GO:0045744Negative regulation of G-protein coupled receptor protein signaling pathwayIDAbiological_process
GO:0046488Phosphatidylinositol metabolic processIDAbiological_process
GO:0050849Negative regulation of calcium-mediated signalingNASbiological_process
GO:0060305Regulation of cell diameterIDAbiological_process
GO:0070493Thrombin receptor signaling pathwayIDAbiological_process
GO:0070527Platelet aggregationISSbiological_process
GO:0070528Protein kinase C signalingISSbiological_process
GO:0070560Protein secretion by plateletISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.93146624370.36266977700.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0177028389
GSE13712_SHEARDown-0.0093552746
GSE13712_STATICDown-0.0056417483
GSE19018Down-0.0129045174
GSE19899_A1Up0.0368821327
GSE19899_A2Up0.3617880681
PubMed_21979375_A1Up0.0291399258
PubMed_21979375_A2Up0.0534268328
GSE35957Up0.0577008762
GSE36640Up0.0418651881
GSE54402Up0.0186329736
GSE9593Down-0.1044751089
GSE43922Down-0.0426387980
GSE24585Down-0.1262262662
GSE37065Down-0.0438694529
GSE28863_A1Down-0.5601249316
GSE28863_A2Down-0.3325852349
GSE28863_A3Up0.0960126994
GSE28863_A4Down-0.0092689412
GSE48662Down-0.1504340021

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.