HCSGD entry for PLG

1. General information

Official gene symbolPLG
Entrez ID5340
Gene full nameplasminogen
Other gene symbols
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0002576Platelet degranulationTASbiological_process
GO:0004175Endopeptidase activityIEAmolecular_function
GO:0004252Serine-type endopeptidase activityIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005576Extracellular regionTAScellular_component
GO:0005615Extracellular spaceIDAcellular_component
GO:0005886Plasma membraneTAScellular_component
GO:0007596Blood coagulationIMP TASbiological_process
GO:0008285Negative regulation of cell proliferationTASbiological_process
GO:0009986Cell surfaceIDAcellular_component
GO:0010812Negative regulation of cell-substrate adhesionIDAbiological_process
GO:0019897Extrinsic component of plasma membraneIEAcellular_component
GO:0019904Protein domain specific bindingIPImolecular_function
GO:0022617Extracellular matrix disassemblyIDA TASbiological_process
GO:0030168Platelet activationTASbiological_process
GO:0030198Extracellular matrix organizationTASbiological_process
GO:0031093Platelet alpha granule lumenTAScellular_component
GO:0031232Extrinsic component of external side of plasma membraneIDAcellular_component
GO:0034185Apolipoprotein bindingIPImolecular_function
GO:0042246Tissue regenerationIEAbiological_process
GO:0042730FibrinolysisTASbiological_process
GO:0043231Intracellular membrane-bounded organelleIEAcellular_component
GO:0044267Cellular protein metabolic processTASbiological_process
GO:0045445Myoblast differentiationIEAbiological_process
GO:0046716Muscle cell cellular homeostasisIEAbiological_process
GO:0048771Tissue remodelingIEAbiological_process
GO:0051603Proteolysis involved in cellular protein catabolic processIEAbiological_process
GO:0051918Negative regulation of fibrinolysisIDAbiological_process
GO:0051919Positive regulation of fibrinolysisIDAbiological_process
GO:0060707Trophoblast giant cell differentiationIEAbiological_process
GO:0060716Labyrinthine layer blood vessel developmentIEAbiological_process
GO:0071674Mononuclear cell migrationIEAbiological_process
GO:2000048Negative regulation of cell-cell adhesion mediated by cadherinTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.54864996390.49857243650.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.1042385533
GSE13712_SHEARUp0.0924040223
GSE13712_STATICUp0.0661198475
GSE19018Up0.0981456085
GSE19899_A1Up0.0486035927
GSE19899_A2Up0.1586909984
PubMed_21979375_A1Up0.2668726229
PubMed_21979375_A2Down-0.1160365512
GSE35957Up0.0937684049
GSE36640Up0.1210192672
GSE54402Up0.1196612349
GSE9593Down-0.0476894890
GSE43922Up0.0088629552
GSE24585Down-0.1675939630
GSE37065Down-0.1591278207
GSE28863_A1Up0.0385576922
GSE28863_A2Up0.0051641998
GSE28863_A3Up0.3413081173
GSE28863_A4Down-0.2559721089
GSE48662Down-0.0007538787

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

AlteplaseDB00009 BTD00050 | BIOD00050
UrokinaseDB00013 BTD00030 | BIOD00030
ReteplaseDB00015 BTD00013 | BIOD00013
AnistreplaseDB00029 BTD00102 | BIOD00102
TenecteplaseDB00031 BTD00019 | BIOD00019
StreptokinaseDB00086 BTD00028 | BIOD00028
BicineDB03709 EXPT00641
DesmoteplaseDB04925 -
AprotininDB06692 -

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.