HCSGD entry for PLEC
1. General information
| Official gene symbol | PLEC |
|---|---|
| Entrez ID | 5339 |
| Gene full name | plectin |
| Other gene symbols | EBS1 EBSO HD1 LGMD2Q PCN PLEC1 PLEC1b PLTN |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003779 | Actin binding | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0005886 | Plasma membrane | NAS | cellular_component |
| GO:0005925 | Focal adhesion | IDA | cellular_component |
| GO:0006915 | Apoptotic process | TAS | biological_process |
| GO:0006921 | Cellular component disassembly involved in execution phase of apoptosis | TAS | biological_process |
| GO:0008307 | Structural constituent of muscle | IMP TAS | molecular_function |
| GO:0016528 | Sarcoplasm | ISS | cellular_component |
| GO:0030056 | Hemidesmosome | IDA | cellular_component |
| GO:0030198 | Extracellular matrix organization | TAS | biological_process |
| GO:0030506 | Ankyrin binding | IPI | molecular_function |
| GO:0031581 | Hemidesmosome assembly | IDA TAS | biological_process |
| GO:0034329 | Cell junction assembly | TAS | biological_process |
| GO:0042383 | Sarcolemma | IDA | cellular_component |
| GO:0043034 | Costamere | TAS | cellular_component |
| GO:0043292 | Contractile fiber | IEA | cellular_component |
| GO:0045111 | Intermediate filament cytoskeleton | IDA | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0351618024 | 0.4067685840 | 0.4282710782 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1729793402 |
| GSE13712_SHEAR | Up | 0.3810840679 |
| GSE13712_STATIC | Down | -0.1221889383 |
| GSE19018 | Up | 0.0216055364 |
| GSE19899_A1 | Down | -0.2645034520 |
| GSE19899_A2 | Down | -0.5889809798 |
| PubMed_21979375_A1 | Up | 0.3223972545 |
| PubMed_21979375_A2 | Up | 1.0310181805 |
| GSE35957 | Up | 0.0071945513 |
| GSE36640 | Up | 0.1609877414 |
| GSE54402 | Down | -0.0847582050 |
| GSE9593 | Up | 1.0653506106 |
| GSE43922 | Down | -0.1189873011 |
| GSE24585 | Down | -0.0307558178 |
| GSE37065 | Down | -0.4451575694 |
| GSE28863_A1 | Up | 0.6118413660 |
| GSE28863_A2 | Up | 0.7092809585 |
| GSE28863_A3 | Up | 0.2227466564 |
| GSE28863_A4 | Up | 0.1198963706 |
| GSE48662 | Up | 0.3860077976 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-7-5p | MIMAT0000252 | MIRT004076 | Microarray | Functional MTI (Weak) | 19073608 |
| hsa-miR-124-3p | MIMAT0000422 | MIRT023142 | Proteomics;Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT032043 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-769-3p | MIMAT0003887 | MIRT039118 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT040211 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 24496748 | Additionally, expression analysis identified PLEC, C8orf48, TRPC4, and ZNF14, as differentially regulated genes in senescent hMSCs that were similarly regulated in those hMSCs which failed to produce a therapeutic effect in a GVHD trial |
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