HCSGD entry for TPCN1
1. General information
| Official gene symbol | TPCN1 |
|---|---|
| Entrez ID | 53373 |
| Gene full name | two pore segment channel 1 |
| Other gene symbols | TPC1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005216 | Ion channel activity | IEA | molecular_function |
| GO:0005244 | Voltage-gated ion channel activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005765 | Lysosomal membrane | IDA TAS | cellular_component |
| GO:0010008 | Endosome membrane | IDA | cellular_component |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0034220 | Ion transmembrane transport | TAS | biological_process |
| GO:0042802 | Identical protein binding | IPI | molecular_function |
| GO:0055085 | Transmembrane transport | TAS | biological_process |
| GO:0072345 | NAADP-sensitive calcium-release channel activity | IDA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0134264542 | 0.9672147601 | 0.2889914146 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0866889038 |
| GSE13712_SHEAR | Down | -0.5404243540 |
| GSE13712_STATIC | Down | -0.1589568897 |
| GSE19018 | Up | 0.1638457847 |
| GSE19899_A1 | Up | 0.0618769729 |
| GSE19899_A2 | Up | 0.5943697042 |
| PubMed_21979375_A1 | Up | 0.0930851693 |
| PubMed_21979375_A2 | Up | 0.2880547216 |
| GSE35957 | Up | 0.1874658591 |
| GSE36640 | Up | 0.4888608588 |
| GSE54402 | Up | 0.2176260283 |
| GSE9593 | Up | 0.4467167013 |
| GSE43922 | Up | 0.6217400004 |
| GSE24585 | Down | -0.1262935676 |
| GSE37065 | Down | -0.0674584504 |
| GSE28863_A1 | Up | 0.9847734120 |
| GSE28863_A2 | Up | 1.4638384615 |
| GSE28863_A3 | Down | -0.1575212910 |
| GSE28863_A4 | Up | 0.0063606735 |
| GSE48662 | Up | 0.7210427590 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT018931 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-23b-3p | MIMAT0000418 | MIRT046365 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
