HCSGD entry for BCL11A

1. General information

Official gene symbolBCL11A
Entrez ID53335
Gene full nameB-cell CLL/lymphoma 11A (zinc finger protein)
Other gene symbolsBCL11A-L BCL11A-S BCL11A-XL BCL11a-M CTIP1 EVI9 HBFQTL5 ZNF856
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0003676Nucleic acid bindingIEAmolecular_function
GO:0003714Transcription corepressor activityIEAmolecular_function
GO:0005634NucleusIDA IEAcellular_component
GO:0005737CytoplasmIEA ISScellular_component
GO:0006351Transcription, DNA-templatedIEAbiological_process
GO:0006355Regulation of transcription, DNA-templatedIEAbiological_process
GO:0010629Negative regulation of gene expressionIEAbiological_process
GO:0010976Positive regulation of neuron projection developmentIDAbiological_process
GO:0010977Negative regulation of neuron projection developmentIDAbiological_process
GO:0016925Protein sumoylationISSbiological_process
GO:0030183B cell differentiationIEAbiological_process
GO:0030217T cell differentiationIEAbiological_process
GO:0030517Negative regulation of axon extensionISSbiological_process
GO:0032463Negative regulation of protein homooligomerizationICbiological_process
GO:0042803Protein homodimerization activityTASmolecular_function
GO:0045944Positive regulation of transcription from RNA polymerase II promoterISSbiological_process
GO:0046872Metal ion bindingIEAmolecular_function
GO:0046982Protein heterodimerization activityIPImolecular_function
GO:0048671Negative regulation of collateral sproutingIMPbiological_process
GO:0048672Positive regulation of collateral sproutingIMPbiological_process
GO:0050773Regulation of dendrite developmentIMPbiological_process
GO:2000171Negative regulation of dendrite developmentIMPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.62295274880.26459623490.99999024730.9866719122

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0723190449
GSE13712_SHEARDown-0.1756079785
GSE13712_STATICDown-0.1538518263
GSE19018Down-0.0966653327
GSE19899_A1Up0.0930592686
GSE19899_A2Up0.1385601102
PubMed_21979375_A1Down-0.3252189944
PubMed_21979375_A2Up0.0124244603
GSE35957Up0.1450204663
GSE36640Up0.4804820202
GSE54402Up0.3102924113
GSE9593Up0.0642966814
GSE43922Down-0.1456836310
GSE24585Down-1.2126042802
GSE37065Down-0.0008034576
GSE28863_A1Down-0.0303489163
GSE28863_A2Down-0.0179588979
GSE28863_A3Up0.3766440046
GSE28863_A4Down-0.0123971451
GSE48662Up0.1700655570

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-148b-3pMIMAT0000759MIRT019481MicroarrayFunctional MTI (Weak)17612493
hsa-miR-340-5pMIMAT0004692MIRT019603SequencingFunctional MTI (Weak)20371350
hsa-miR-29c-3pMIMAT0000681MIRT020396SequencingFunctional MTI (Weak)20371350
hsa-miR-196a-5pMIMAT0000226MIRT026052SequencingFunctional MTI (Weak)20371350
hsa-miR-32-5pMIMAT0000090MIRT028335SequencingFunctional MTI (Weak)20371350
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.