HCSGD entry for PLCB4
1. General information
| Official gene symbol | PLCB4 |
|---|---|
| Entrez ID | 5332 |
| Gene full name | phospholipase C, beta 4 |
| Other gene symbols | ARCND2 PI-PLC |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004435 | Phosphatidylinositol phospholipase C activity | IEA | molecular_function |
| GO:0004629 | Phospholipase C activity | IEA TAS | molecular_function |
| GO:0004871 | Signal transducer activity | IEA | molecular_function |
| GO:0005509 | Calcium ion binding | IEA | molecular_function |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0005790 | Smooth endoplasmic reticulum | IEA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006629 | Lipid metabolic process | IEA | biological_process |
| GO:0007602 | Phototransduction | IEA | biological_process |
| GO:0014069 | Postsynaptic density | IEA | cellular_component |
| GO:0016042 | Lipid catabolic process | IEA | biological_process |
| GO:0030425 | Dendrite | IEA | cellular_component |
| GO:0035556 | Intracellular signal transduction | IEA | biological_process |
| GO:0043647 | Inositol phosphate metabolic process | TAS | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0699278827 | 0.0001868166 | 0.5654598464 | 0.0245860000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.4777343223 |
| GSE13712_SHEAR | Down | -1.5920901934 |
| GSE13712_STATIC | Down | -0.4271077459 |
| GSE19018 | Up | 1.5357475245 |
| GSE19899_A1 | Down | -2.0602233785 |
| GSE19899_A2 | Down | -2.8675747950 |
| PubMed_21979375_A1 | Down | -2.6812262705 |
| PubMed_21979375_A2 | Down | -3.4760541214 |
| GSE35957 | Up | 2.0258333928 |
| GSE36640 | Up | 3.6937289265 |
| GSE54402 | Down | -1.4257793797 |
| GSE9593 | Up | 0.1678713370 |
| GSE43922 | Down | -1.8053469534 |
| GSE24585 | Up | 0.3663944956 |
| GSE37065 | Down | -0.1125705863 |
| GSE28863_A1 | Down | -1.4758905049 |
| GSE28863_A2 | Down | -0.4159078189 |
| GSE28863_A3 | Down | -0.5228315860 |
| GSE28863_A4 | Up | 0.0420034369 |
| GSE48662 | Up | 0.2165309450 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-9-5p | MIMAT0000441 | MIRT021355 | Microarray | Functional MTI (Weak) | 17612493 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT028848 | Microarray | Functional MTI (Weak) | 19088304 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
