HCSGD entry for PLCB2
1. General information
| Official gene symbol | PLCB2 |
|---|---|
| Entrez ID | 5330 |
| Gene full name | phospholipase C, beta 2 |
| Other gene symbols | |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004435 | Phosphatidylinositol phospholipase C activity | IEA | molecular_function |
| GO:0004629 | Phospholipase C activity | IEA TAS | molecular_function |
| GO:0004871 | Signal transducer activity | IEA | molecular_function |
| GO:0005509 | Calcium ion binding | IEA | molecular_function |
| GO:0005737 | Cytoplasm | IEA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006629 | Lipid metabolic process | IEA | biological_process |
| GO:0006644 | Phospholipid metabolic process | TAS | biological_process |
| GO:0007202 | Activation of phospholipase C activity | TAS | biological_process |
| GO:0007268 | Synaptic transmission | TAS | biological_process |
| GO:0016042 | Lipid catabolic process | IEA | biological_process |
| GO:0035556 | Intracellular signal transduction | IEA | biological_process |
| GO:0043647 | Inositol phosphate metabolic process | TAS | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0050913 | Sensory perception of bitter taste | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.8002635842 | 0.6588685422 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1649432093 |
| GSE13712_SHEAR | Down | -0.0886217592 |
| GSE13712_STATIC | Down | -0.1848441636 |
| GSE19018 | Down | -0.1185578162 |
| GSE19899_A1 | Up | 0.0201988487 |
| GSE19899_A2 | Up | 0.2153728354 |
| PubMed_21979375_A1 | Up | 0.0120528762 |
| PubMed_21979375_A2 | Down | -0.0548336823 |
| GSE35957 | Up | 0.3441390387 |
| GSE36640 | Up | 0.0664548705 |
| GSE54402 | Up | 0.0516104682 |
| GSE9593 | Up | 0.0741082960 |
| GSE43922 | Up | 0.0113698460 |
| GSE24585 | Up | 0.0567830158 |
| GSE37065 | Up | 0.0112901266 |
| GSE28863_A1 | Down | -0.1625990909 |
| GSE28863_A2 | Down | -0.1707516408 |
| GSE28863_A3 | Up | 0.3525386755 |
| GSE28863_A4 | Up | 0.1331133798 |
| GSE48662 | Down | -0.2061263034 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-26b-5p | MIMAT0000083 | MIRT028821 | Microarray | Functional MTI (Weak) | 19088304 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
