HCSGD entry for PLAU
1. General information
| Official gene symbol | PLAU |
|---|---|
| Entrez ID | 5328 |
| Gene full name | plasminogen activator, urokinase |
| Other gene symbols | ATF BDPLT5 QPD UPA URK u-PA |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001666 | Response to hypoxia | IEA | biological_process |
| GO:0004252 | Serine-type endopeptidase activity | IEA TAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005576 | Extracellular region | TAS | cellular_component |
| GO:0005615 | Extracellular space | IDA | cellular_component |
| GO:0005886 | Plasma membrane | TAS | cellular_component |
| GO:0006508 | Proteolysis | IEA | biological_process |
| GO:0006935 | Chemotaxis | TAS | biological_process |
| GO:0007165 | Signal transduction | TAS | biological_process |
| GO:0007596 | Blood coagulation | TAS | biological_process |
| GO:0009986 | Cell surface | IDA | cellular_component |
| GO:0010469 | Regulation of receptor activity | IDA | biological_process |
| GO:0014909 | Smooth muscle cell migration | IEA | biological_process |
| GO:0014910 | Regulation of smooth muscle cell migration | IDA | biological_process |
| GO:0033628 | Regulation of cell adhesion mediated by integrin | IDA | biological_process |
| GO:0042127 | Regulation of cell proliferation | IEA | biological_process |
| GO:0042730 | Fibrinolysis | IEA TAS | biological_process |
| GO:0061041 | Regulation of wound healing | IC | biological_process |
| GO:2000097 | Regulation of smooth muscle cell-matrix adhesion | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0001168877 | 0.8947215037 | 0.0300902913 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 3.0432464492 |
| GSE13712_SHEAR | Up | 1.2156918821 |
| GSE13712_STATIC | Up | 1.8026883080 |
| GSE19018 | Down | -2.0165819757 |
| GSE19899_A1 | Up | 0.3771726978 |
| GSE19899_A2 | Up | 1.0479912186 |
| PubMed_21979375_A1 | Up | 1.6046774220 |
| PubMed_21979375_A2 | Up | 0.5138017342 |
| GSE35957 | Up | 0.2340079478 |
| GSE36640 | Up | 0.0999101083 |
| GSE54402 | Up | 0.7355491790 |
| GSE9593 | Up | 0.4484582898 |
| GSE43922 | Up | 1.2114066879 |
| GSE24585 | Up | 0.1738857003 |
| GSE37065 | Down | -0.4289680589 |
| GSE28863_A1 | Up | 0.8607723469 |
| GSE28863_A2 | Up | 0.6926894493 |
| GSE28863_A3 | Up | 0.5233004918 |
| GSE28863_A4 | Up | 0.3520309812 |
| GSE48662 | Down | -0.0411043401 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
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- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-23b-3p | MIMAT0000418 | MIRT004291 | Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 19490101 |
| hsa-miR-23b-3p | MIMAT0000418 | MIRT004291 | qRT-PCR//Western blot | Functional MTI | 21242962 |
| hsa-miR-193b-3p | MIMAT0002819 | MIRT004413 | Western blot//Luciferase reporter assay | Functional MTI | 19701247 |
| hsa-miR-215-5p | MIMAT0000272 | MIRT024290 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-192-5p | MIMAT0000222 | MIRT026220 | Microarray | Functional MTI (Weak) | 19074876 |
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- mirRecord
- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-193b-3p | MIMAT0002819 | 1 | hsa-miR-193b | {Western blot} | {downregulation} | 19701247 | |
| hsa-miR-23b-3p | MIMAT0000418 | 1 | hsa-miR-23b | {Western blot} | {overexpression by miRNA mimics tranfection} | 19490101 | |
| hsa-miR-23b-3p | MIMAT0000418 | 2 | hsa-miR-23b | {Western blot} | {overexpression by miRNA mimics tranfection} | 19490101 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 4 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 27127888 | Only PLAU, JUN, and FOS were related to DNA damage, telomere dysfunction-induced aging markers, neutrophil function and IgA nephropathy |
| 17172853 | PAI-1 antagonizes the protease urokinase-type plasminogen activator (uPA) |
| 8706787 | Young and senescent cells were compared in quiescent and activated growth conditions for the secretion of tissue-type plasminogen activator (t-PA), urokinase-type plasminogen activator (u-PA), plasminogen activator inhibitor-1 (PAI-1) and plasminogen activator inhibitor-2 (PAI-2) |
| 8706787 | RNA analysis revealed that senescent lung and skin cells, independent of the growth state, constitutively express levels of u-PA and PAI-1 comparable to the expression levels in young mitotically growing cells |
| 8706787 | 5% fetal calf serum (FCS) for five days, with the majority of the activity co-migrating on zymograms with u-PA |
| 3300618 | The cells secreted tissue-type plasminogen activator (t-PA) and PA inhibitor-1, and, after subculturing, urokinase-type PA (u-PA) antigen |
| 3300618 | 3) The release of u-PA antigen varied |
| 3300618 | No u-PA antigen was detectable in conditioned medium of primary cultures of human aorta and vena cava endothelial cells or of early passage vena cava cells |
| 3300618 | After prolonged subculturing, vena cava cells started to secrete u-PA |
| 3300618 | Endothelial cells from aorta and other adult arteries, however, started secreting u-PA after one to four passages, parallel to the occurrence of enlarged endothelial cells |
| 3300618 | Our data suggest that the release of u-PA antigen by human macrovascular endothelial cells can be used as an indicator of cell senescence |
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