HCSGD entry for PLAGL1
1. General information
| Official gene symbol | PLAGL1 |
|---|---|
| Entrez ID | 5325 |
| Gene full name | pleiomorphic adenoma gene-like 1 |
| Other gene symbols | LOT1 ZAC ZAC1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000981 | Sequence-specific DNA binding RNA polymerase II transcription factor activity | IBA | molecular_function |
| GO:0003676 | Nucleic acid binding | IEA | molecular_function |
| GO:0003677 | DNA binding | IDA | molecular_function |
| GO:0003700 | Sequence-specific DNA binding transcription factor activity | IEA | molecular_function |
| GO:0005634 | Nucleus | IBA IEA | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0006366 | Transcription from RNA polymerase II promoter | IBA | biological_process |
| GO:0006915 | Apoptotic process | IEA | biological_process |
| GO:0007050 | Cell cycle arrest | TAS | biological_process |
| GO:0030154 | Cell differentiation | IBA | biological_process |
| GO:0035914 | Skeletal muscle cell differentiation | IEA | biological_process |
| GO:0045944 | Positive regulation of transcription from RNA polymerase II promoter | IDA IEA | biological_process |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0575003723 | 0.0859241404 | 0.5208685293 | 0.5573211681 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -1.0504938972 |
| GSE13712_SHEAR | Up | 0.4094264275 |
| GSE13712_STATIC | Up | 0.1551448093 |
| GSE19018 | Up | 1.7788061174 |
| GSE19899_A1 | Down | -1.4275031711 |
| GSE19899_A2 | Down | -0.0160851948 |
| PubMed_21979375_A1 | Up | 0.6112627366 |
| PubMed_21979375_A2 | Down | -0.1219685883 |
| GSE35957 | Up | 1.1999186271 |
| GSE36640 | Up | 0.0051336287 |
| GSE54402 | Down | -0.5351354820 |
| GSE9593 | Up | 0.0843021774 |
| GSE43922 | Down | -0.3549851548 |
| GSE24585 | Up | 0.0950458121 |
| GSE37065 | Up | 0.1873431068 |
| GSE28863_A1 | Up | 0.4449607214 |
| GSE28863_A2 | Up | 0.4972153402 |
| GSE28863_A3 | Down | -0.4423676799 |
| GSE28863_A4 | Down | -0.2559596630 |
| GSE48662 | Down | -0.1734341876 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-98-5p | MIMAT0000096 | MIRT027731 | Microarray | Functional MTI (Weak) | 19088304 |
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- mirRecord
- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-125b-5p | MIMAT0000423 | NA | hsa-miR-125b | 21935352 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
