HCSGD entry for PLAG1
1. General information
| Official gene symbol | PLAG1 |
|---|---|
| Entrez ID | 5324 |
| Gene full name | pleiomorphic adenoma gene 1 |
| Other gene symbols | PSA SGPA ZNF912 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000981 | Sequence-specific DNA binding RNA polymerase II transcription factor activity | IBA | molecular_function |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0003700 | Sequence-specific DNA binding transcription factor activity | TAS | molecular_function |
| GO:0005634 | Nucleus | IBA | cellular_component |
| GO:0006357 | Regulation of transcription from RNA polymerase II promoter | IBA | biological_process |
| GO:0006366 | Transcription from RNA polymerase II promoter | IBA | biological_process |
| GO:0010628 | Positive regulation of gene expression | IEA | biological_process |
| GO:0010629 | Negative regulation of gene expression | IEA | biological_process |
| GO:0022612 | Gland morphogenesis | IEA | biological_process |
| GO:0035264 | Multicellular organism growth | IEA | biological_process |
| GO:0035265 | Organ growth | IEA | biological_process |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
| GO:0060252 | Positive regulation of glial cell proliferation | IEA | biological_process |
| GO:0060736 | Prostate gland growth | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0783400973 | 0.0091400859 | 0.5905995418 | 0.1887905882 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0450645027 |
| GSE13712_SHEAR | Down | -0.4512241204 |
| GSE13712_STATIC | Down | -0.9532153293 |
| GSE19018 | Up | 1.0463754399 |
| GSE19899_A1 | Down | -0.6342756897 |
| GSE19899_A2 | Down | -0.9957863108 |
| PubMed_21979375_A1 | Down | -1.3498360533 |
| PubMed_21979375_A2 | Down | -1.0924010931 |
| GSE35957 | Up | 1.1113237296 |
| GSE36640 | Up | 0.5352067110 |
| GSE54402 | Down | -0.6173618415 |
| GSE9593 | Up | 0.8116697246 |
| GSE43922 | Down | -0.3933401889 |
| GSE24585 | Up | 0.2450114422 |
| GSE37065 | Up | 0.8454651767 |
| GSE28863_A1 | Up | 0.1966560296 |
| GSE28863_A2 | Up | 0.4970355274 |
| GSE28863_A3 | Down | -1.3075418150 |
| GSE28863_A4 | Down | -0.2939559658 |
| GSE48662 | Up | 0.2880940725 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-107 | MIMAT0000104 | MIRT000371 | Luciferase reporter assay | Functional MTI | 19692702 |
| hsa-miR-424-5p | MIMAT0001341 | MIRT000696 | Western blot//Luciferase reporter assay//Microarray | Functional MTI | 19692702 |
| hsa-miR-181b-5p | MIMAT0000257 | MIRT000697 | Western blot//Luciferase reporter assay//Microarray | Functional MTI | 19692702 |
| hsa-miR-181a-5p | MIMAT0000256 | MIRT000698 | Western blot//Luciferase reporter assay//Microarray | Functional MTI | 19692702 |
| hsa-miR-26a-5p | MIMAT0000082 | MIRT001772 | Luciferase reporter assay//Microarray//Reporter assay;Other | Functional MTI | 16461460 |
| hsa-miR-375 | MIMAT0000728 | MIRT003057 | Luciferase reporter assay | Functional MTI | 19347935 |
| hsa-miR-144-3p | MIMAT0000436 | MIRT003058 | Luciferase reporter assay | Functional MTI | 19347935 |
| hsa-miR-340-5p | MIMAT0004692 | MIRT019551 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-29c-3p | MIMAT0000681 | MIRT020407 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-128-3p | MIMAT0000424 | MIRT022011 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-103a-3p | MIMAT0000101 | MIRT027129 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-101-3p | MIMAT0000099 | MIRT027278 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-98-5p | MIMAT0000096 | MIRT027581 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-27a-3p | MIMAT0000084 | MIRT028712 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT029202 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT031591 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-17-5p | MIMAT0000070 | MIRT051002 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-26a-5p | MIMAT0000082 | NA | hsa-miR-26a | {activity assay} | {overexpression by mature miRNA transfection} | {luciferase} | 16461460 |
| hsa-miR-181a-5p | MIMAT0000256 | NA | hsa-miR-181a | 19692702 | |||
| hsa-miR-181b-5p | MIMAT0000257 | NA | hsa-miR-181b | 19692702 | |||
| hsa-miR-424-5p | MIMAT0001341 | NA | hsa-miR-424 | 19692702 | |||
| hsa-miR-107 | MIMAT0000104 | NA | hsa-miR-107 | 19692702 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
