HCSGD entry for PKLR

1. General information

Official gene symbolPKLR
Entrez ID5313
Gene full namepyruvate kinase, liver and RBC
Other gene symbolsPK1 PKL PKR PKRL RPK
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000287Magnesium ion bindingIEAmolecular_function
GO:0001666Response to hypoxiaIEAbiological_process
GO:0004743Pyruvate kinase activityIEAmolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005829CytosolTAScellular_component
GO:0005975Carbohydrate metabolic processTASbiological_process
GO:0006006Glucose metabolic processTASbiological_process
GO:0006096GlycolysisIEA TASbiological_process
GO:0006112Energy reserve metabolic processTASbiological_process
GO:0006754ATP biosynthetic processIEAbiological_process
GO:0007584Response to nutrientIEAbiological_process
GO:0009408Response to heatIEAbiological_process
GO:0009749Response to glucoseIEAbiological_process
GO:0010226Response to lithium ionIEAbiological_process
GO:0030955Potassium ion bindingIEAmolecular_function
GO:0031018Endocrine pancreas developmentTASbiological_process
GO:0031325Positive regulation of cellular metabolic processTASbiological_process
GO:0032869Cellular response to insulin stimulusIEAbiological_process
GO:0033198Response to ATPIEAbiological_process
GO:0042866Pyruvate biosynthetic processIEAbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0051591Response to cAMPIEAbiological_process
GO:0051707Response to other organismIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.43407827590.93079700240.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0151066555
GSE13712_SHEARDown-0.0315226825
GSE13712_STATICUp0.0206402793
GSE19018Up0.0171482418
GSE19899_A1Up0.0230145422
GSE19899_A2Up0.0893570031
PubMed_21979375_A1Down-0.1711891334
PubMed_21979375_A2Up0.0803453066
GSE35957Up0.2011713068
GSE36640Up0.3702173781
GSE54402Down-0.1479602556
GSE9593Down-0.0148906263
GSE43922Up0.0976485902
GSE24585Up0.3008209981
GSE37065Down-0.0057954676
GSE28863_A1Down-0.0523467440
GSE28863_A2Up0.1082788915
GSE28863_A3Up0.1521060777
GSE28863_A4Up0.2080435000
GSE48662Down-0.0823284131

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

2-Phosphoglycolic AcidDB02726 EXPT02567 | DB02389
beta-D-fructofuranose 1,6-bisphosphateDB04551 EXPT01395

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

6885337In man, patients with hereditary red cell pyruvate kinase (PK) deficiency have their enzyme concomitantly affected in both red cells and liver (PK-L), such that red cell L' and liver L PK subunits appear to be encoded by the same structural gene
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