HCSGD entry for PIN1
1. General information
| Official gene symbol | PIN1 |
|---|---|
| Entrez ID | 5300 |
| Gene full name | peptidylprolyl cis/trans isomerase, NIMA-interacting 1 |
| Other gene symbols | DOD UBL5 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000413 | Protein peptidyl-prolyl isomerization | IDA | biological_process |
| GO:0001934 | Positive regulation of protein phosphorylation | IGI | biological_process |
| GO:0003755 | Peptidyl-prolyl cis-trans isomerase activity | IDA IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0005737 | Cytoplasm | IEA | cellular_component |
| GO:0006457 | Protein folding | IEA | biological_process |
| GO:0007049 | Cell cycle | IEA | biological_process |
| GO:0007088 | Regulation of mitosis | TAS | biological_process |
| GO:0016607 | Nuclear speck | IEA | cellular_component |
| GO:0019221 | Cytokine-mediated signaling pathway | TAS | biological_process |
| GO:0030496 | Midbody | IDA | cellular_component |
| GO:0030512 | Negative regulation of transforming growth factor beta receptor signaling pathway | IDA | biological_process |
| GO:0031434 | Mitogen-activated protein kinase kinase binding | IPI | molecular_function |
| GO:0032321 | Positive regulation of Rho GTPase activity | IMP | biological_process |
| GO:0032465 | Regulation of cytokinesis | IGI IMP | biological_process |
| GO:0032480 | Negative regulation of type I interferon production | TAS | biological_process |
| GO:0032794 | GTPase activating protein binding | IPI | molecular_function |
| GO:0045087 | Innate immune response | TAS | biological_process |
| GO:0050815 | Phosphoserine binding | IDA | molecular_function |
| GO:0050816 | Phosphothreonine binding | IDA IPI | molecular_function |
| GO:0051443 | Positive regulation of ubiquitin-protein ligase activity | IDA | biological_process |
| GO:0060393 | Regulation of pathway-restricted SMAD protein phosphorylation | IDA | biological_process |
| GO:0070373 | Negative regulation of ERK1 and ERK2 cascade | IDA | biological_process |
| GO:2000146 | Negative regulation of cell motility | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.2109502071 | 0.5059029862 | 0.8847969890 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.2956027511 |
| GSE13712_SHEAR | Down | -0.1396095156 |
| GSE13712_STATIC | Up | 0.0098104446 |
| GSE19018 | Up | 0.6308533208 |
| GSE19899_A1 | Down | -0.3140777563 |
| GSE19899_A2 | Up | 0.5020684492 |
| PubMed_21979375_A1 | Up | 1.0798397199 |
| PubMed_21979375_A2 | Down | -0.1607555712 |
| GSE35957 | Up | 0.4473720356 |
| GSE36640 | Up | 0.0682154669 |
| GSE54402 | Up | 0.0923190637 |
| GSE9593 | Up | 0.1145094742 |
| GSE43922 | Down | -0.0368606539 |
| GSE24585 | Down | -0.1662357773 |
| GSE37065 | Down | -0.0172947015 |
| GSE28863_A1 | Down | -0.4439072098 |
| GSE28863_A2 | Down | -0.2340000454 |
| GSE28863_A3 | Down | -0.1333983386 |
| GSE28863_A4 | Up | 0.1148656916 |
| GSE48662 | Up | 0.1365238780 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
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- Drugs
Name | Drug | Accession number |
|---|---|---|
| Beta-(2-Naphthyl)-Alanine | DB01766 | EXPT02291 |
| 3,6,9,12,15,18-HEXAOXAICOSANE | DB06867 | - |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-484 | MIMAT0002174 | MIRT042314 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-324-5p | MIMAT0000761 | MIRT043127 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 24272483 | Here, we report that cyclophilin B (CypB), a prolyl isomerase residing in the endoplasmic reticulum (ER), provides an essential survival signal in glioblastoma multiforme cells |
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