HCSGD entry for PIK3R1

1. General information

Official gene symbolPIK3R1
Entrez ID5295
Gene full namephosphoinositide-3-kinase, regulatory subunit 1 (alpha)
Other gene symbolsAGM7 GRB1 p85 p85-ALPHA
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001953Negative regulation of cell-matrix adhesionIEAbiological_process
GO:0005068Transmembrane receptor protein tyrosine kinase adaptor activityISSmolecular_function
GO:0005158Insulin receptor bindingIPImolecular_function
GO:0005159Insulin-like growth factor receptor bindingIPImolecular_function
GO:0005168Neurotrophin TRKA receptor bindingIPImolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005829CytosolTAScellular_component
GO:0005886Plasma membraneTAScellular_component
GO:0005942Phosphatidylinositol 3-kinase complexIEA ISScellular_component
GO:00059431-phosphatidylinositol-4-phosphate 3-kinase, class IA complexISScellular_component
GO:0006468Protein phosphorylationIEAbiological_process
GO:0006644Phospholipid metabolic processTASbiological_process
GO:0006661Phosphatidylinositol biosynthetic processTASbiological_process
GO:0007165Signal transductionIEAbiological_process
GO:0007173Epidermal growth factor receptor signaling pathwayTASbiological_process
GO:0007596Blood coagulationTASbiological_process
GO:0008286Insulin receptor signaling pathwayIPI TASbiological_process
GO:0008543Fibroblast growth factor receptor signaling pathwayTASbiological_process
GO:0008625Extrinsic apoptotic signaling pathway via death domain receptorsIEAbiological_process
GO:0008630Intrinsic apoptotic signaling pathway in response to DNA damageIEAbiological_process
GO:0009967Positive regulation of signal transductionISSbiological_process
GO:0014065Phosphatidylinositol 3-kinase signalingIDAbiological_process
GO:0016020MembraneIEAcellular_component
GO:0016032Viral processIEAbiological_process
GO:0019903Protein phosphatase bindingIPImolecular_function
GO:0030168Platelet activationTASbiological_process
GO:0030183B cell differentiationIEAbiological_process
GO:0030335Positive regulation of cell migrationIEAbiological_process
GO:0031295T cell costimulationTASbiological_process
GO:0032760Positive regulation of tumor necrosis factor productionIEAbiological_process
GO:0034644Cellular response to UVIEAbiological_process
GO:0035014Phosphatidylinositol 3-kinase regulator activityIEA ISSmolecular_function
GO:0038095Fc-epsilon receptor signaling pathwayTASbiological_process
GO:0038096Fc-gamma receptor signaling pathway involved in phagocytosisTASbiological_process
GO:0043066Negative regulation of apoptotic processIEAbiological_process
GO:0043125ErbB-3 class receptor bindingIDAmolecular_function
GO:0043548Phosphatidylinositol 3-kinase bindingISSmolecular_function
GO:0043551Regulation of phosphatidylinositol 3-kinase activityISSbiological_process
GO:0043559Insulin bindingIDAmolecular_function
GO:0043560Insulin receptor substrate bindingIEA ISSmolecular_function
GO:0044281Small molecule metabolic processTASbiological_process
GO:0045087Innate immune responseTASbiological_process
GO:0045671Negative regulation of osteoclast differentiationIEAbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIEAbiological_process
GO:0046326Positive regulation of glucose importISSbiological_process
GO:0046854Phosphatidylinositol phosphorylationISSbiological_process
GO:0048009Insulin-like growth factor receptor signaling pathwayIDA IPIbiological_process
GO:0048011Neurotrophin TRK receptor signaling pathwayTASbiological_process
GO:0048015Phosphatidylinositol-mediated signalingTASbiological_process
GO:0050852T cell receptor signaling pathwayTASbiological_process
GO:0050900Leukocyte migrationTASbiological_process
GO:0051531NFAT protein import into nucleusIEAbiological_process
GO:0060396Growth hormone receptor signaling pathwayIDAbiological_process
GO:0090004Positive regulation of establishment of protein localization to plasma membraneISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.02828542990.27805660500.39101932771.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.3103392854
GSE13712_SHEARUp0.4361960212
GSE13712_STATICUp0.0324576280
GSE19018Down-0.8822295166
GSE19899_A1Down-0.1970576868
GSE19899_A2Up0.2070867799
PubMed_21979375_A1Up0.4875183324
PubMed_21979375_A2Up0.4151925048
GSE35957Up2.4489830122
GSE36640Up0.5048325635
GSE54402Up0.2202606881
GSE9593Up0.0058447703
GSE43922Up0.0009358672
GSE24585Up0.2671907028
GSE37065Up0.4541011760
GSE28863_A1Up0.6468916636
GSE28863_A2Up0.1998608125
GSE28863_A3Down-0.5362502008
GSE28863_A4Down-0.4717806073
GSE48662Down-0.2803158168

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Compound

Target

Confidence score

Uniprot

CHEMBL127907CHEMBL25068P27986
CHEMBL104468CHEMBL25068P27986
CHEMBL98350CHEMBL25068P27986
CHEMBL50CHEMBL25068P27986
CHEMBL137056CHEMBL25068P27986
CHEMBL137257CHEMBL25068P27986
CHEMBL337527CHEMBL25068P27986
CHEMBL137706CHEMBL25068P27986
CHEMBL136180CHEMBL25068P27986
CHEMBL137060CHEMBL25068P27986
CHEMBL327958CHEMBL25068P27986
CHEMBL335862CHEMBL25068P27986
CHEMBL135728CHEMBL25068P27986
CHEMBL334693CHEMBL25068P27986
CHEMBL134623CHEMBL25068P27986
CHEMBL421929CHEMBL25068P27986
CHEMBL343074CHEMBL25068P27986
CHEMBL334689CHEMBL25068P27986
CHEMBL137653CHEMBL25068P27986
CHEMBL137715CHEMBL25068P27986
CHEMBL342164CHEMBL25068P27986
CHEMBL137257CHEMBL25068P27986
CHEMBL133031CHEMBL25068P27986
CHEMBL341913CHEMBL25068P27986
CHEMBL539942CHEMBL25068P27986
CHEMBL136171CHEMBL25068P27986
CHEMBL136232CHEMBL25068P27986
CHEMBL136289CHEMBL25068P27986
CHEMBL405059CHEMBL25068P27986
CHEMBL336451CHEMBL25068P27986
CHEMBL1957502CHEMBL25067P27986
CHEMBL1957508CHEMBL25067P27986
CHEMBL1957504CHEMBL25067P27986
CHEMBL1957499CHEMBL25067P27986
CHEMBL1957500CHEMBL25067P27986
CHEMBL1957505CHEMBL25067P27986
CHEMBL1957498CHEMBL25067P27986
CHEMBL382875CHEMBL25067P27986
CHEMBL1957508CHEMBL25067P27986
CHEMBL205591CHEMBL25067P27986
CHEMBL208279CHEMBL25067P27986
CHEMBL381040CHEMBL25067P27986
CHEMBL1957505CHEMBL25067P27986
CHEMBL1957500CHEMBL25067P27986
CHEMBL1957499CHEMBL25067P27986
CHEMBL383037CHEMBL25067P27986
CHEMBL428496CHEMBL25067P27986
CHEMBL1957502CHEMBL25067P27986
CHEMBL383415CHEMBL25067P27986
CHEMBL1957497CHEMBL25067P27986
CHEMBL1957504CHEMBL25067P27986
CHEMBL1957498CHEMBL25067P27986
CHEMBL1957497CHEMBL25067P27986
CHEMBL1957507CHEMBL25067P27986
CHEMBL1957506CHEMBL25067P27986
CHEMBL1957498CHEMBL25067P27986
CHEMBL1957508CHEMBL25067P27986
CHEMBL1957502CHEMBL25067P27986
CHEMBL1957505CHEMBL25067P27986
CHEMBL1957501CHEMBL25067P27986
CHEMBL1957500CHEMBL25067P27986
CHEMBL1957503CHEMBL25067P27986
CHEMBL1957504CHEMBL25067P27986
CHEMBL1957497CHEMBL25067P27986
CHEMBL1957499CHEMBL25067P27986
CHEMBL1256459CHEMBL25066P27986
CHEMBL1765602CHEMBL25066P27986
CHEMBL1765602CHEMBL25066P27986
CHEMBL1256459CHEMBL25066P27986
CHEMBL1957498CHEMBL25066P27986
CHEMBL1957497CHEMBL25066P27986
CHEMBL1957504CHEMBL25066P27986
CHEMBL1957488CHEMBL25066P27986
CHEMBL1957496CHEMBL25066P27986
CHEMBL1957491CHEMBL25066P27986
CHEMBL1957486CHEMBL25066P27986
CHEMBL1957490CHEMBL25066P27986
CHEMBL1957502CHEMBL25066P27986
CHEMBL1957507CHEMBL25066P27986
CHEMBL1957506CHEMBL25066P27986
CHEMBL1957495CHEMBL25066P27986
CHEMBL1957494CHEMBL25066P27986
CHEMBL1957485CHEMBL25066P27986
CHEMBL1957493CHEMBL25066P27986
CHEMBL1957503CHEMBL25066P27986
CHEMBL1957499CHEMBL25066P27986
CHEMBL1957484CHEMBL25066P27986
CHEMBL1957487CHEMBL25066P27986
CHEMBL1957505CHEMBL25066P27986
CHEMBL1957508CHEMBL25066P27986
CHEMBL1957489CHEMBL25066P27986
CHEMBL1957492CHEMBL25066P27986
CHEMBL1957501CHEMBL25066P27986
CHEMBL1957500CHEMBL25066P27986
CHEMBL1795875CHEMBL25064P27986
CHEMBL49860CHEMBL25064P27986
CHEMBL1795875CHEMBL25064P27986
CHEMBL112635CHEMBL25064P27986
CHEMBL300015CHEMBL25064P27986
CHEMBL300015CHEMBL25064P27986
CHEMBL51941CHEMBL25064P27986
CHEMBL12253CHEMBL25064P27986
CHEMBL7519CHEMBL25064P27986
CHEMBL52450CHEMBL25064P27986
CHEMBL301619CHEMBL25064P27986
CHEMBL52389CHEMBL25064P27986
CHEMBL48761CHEMBL25064P27986
CHEMBL112884CHEMBL25064P27986
CHEMBL7957CHEMBL25064P27986
CHEMBL428835CHEMBL25064P27986
CHEMBL51940CHEMBL25064P27986
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  • Drugs

Name

Drug

Accession number

SF1126DB05210 -
(1S,6BR,9AS,11R,11BR)-9A,11B-DIMETHYL-1-[(METHYLOXY)METHYL]-3,6,9-TRIOXO-1,6,6B,7,8,9,9A,10,11,11B-DECAHYDRO-3H-FURO[4,3,2-DE]INDENO[4,5-H][2]BENZOPYRAN-11-YL ACETATEDB08059 -

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-29a-3pMIMAT0000086MIRT004103Luciferase reporter assay//Northern blot//qRT-PCR//Western blotFunctional MTI20943204
hsa-miR-376a-3pMIMAT0000729MIRT006724Luciferase reporter assay//qRT-PCR//Western blotFunctional MTI22684007
hsa-miR-21-5pMIMAT0000076MIRT030860MicroarrayFunctional MTI (Weak)18591254
hsa-let-7a-5pMIMAT0000062MIRT052505CLASHFunctional MTI (Weak)23622248
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    • mirRecord

MicroRNA name

mirBase ID

Target site number

MiRNA mature ID

Test method inter

MiRNA regulation site

Reporter target site

Pubmed ID

hsa-miR-29a-3pMIMAT00000861hsa-miR-29a{Western blot}{overexpression by mature miRNA transfection}19079265
hsa-miR-29c-3pMIMAT00006811hsa-miR-29c{Western blot}{overexpression by mature miRNA transfection}19079265
hsa-miR-29b-3pMIMAT00001001hsa-miR-29b{Western blot}{overexpression by mature miRNA transfection}19079265
hsa-miR-221-3pMIMAT00002781hsa-miR-221{Western blot}{downregulation}20505758
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6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

24659628With aging, p85alpha, IGF-1 and B-myb muscle levels were lower while the expression of certain cell arrest proteins (p53, p16 and pRB) increased
24659628Impaired MPC proliferation resulted from interactions between miR-29 and the 3'-UTR of p85a, IGF-1 and B-myb, suppressing the translation of these mediators of myoblast proliferation
24659628Thus, aging-induced muscle senescence results from activation of miR-29 by Wnt-3a leading to suppressed expression of several signaling proteins (p85alpha, IGF-1 and B-myb) that act coordinately to impair the proliferation of MPCs contributing to muscle atrophy
21324896Increased cell growth, higher proliferation rate and reduced number of senescent cells were observed in MSCs lacking p85alpha compare with WT MSCs as evaluated by CFU-F assay, thymidine incorporation assay, and beta-galactosidase staining, respectively
21324896In addition, a time-dependent reduction in alkaline phosphatase (ALP) activity and osteocalcin mRNA expression was observed in p85alpha(-/-) MSCs compared with WT MSCs, suggesting impaired osteoblast differentiation due to p85alpha deficiency in MSCs
21324896The impaired p85alpha(-/-) osteoblast differentiation was associated with increased activation of Akt and MAPK
21324896Importantly, bone morphogenic protein 2 (BMP2) was able to intensify the differentiation of osteoblasts derived from WT MSCs, whereas this process was significantly impaired as a result of p85alpha deficiency
21324896However, application of PD98059, a Mek/MAPK inhibitor, significantly enhanced osteoblast differentiation in WT and p85alpha(-/-) MSCs
21324896These results suggest that p85alpha plays an essential role in osteoblast differentiation from MSCs by repressing the activation of MAPK pathway
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