HCSGD entry for PIK3C2B
1. General information
| Official gene symbol | PIK3C2B |
|---|---|
| Entrez ID | 5287 |
| Gene full name | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta |
| Other gene symbols | C2-PI3K |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001727 | Lipid kinase activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0005783 | Endoplasmic reticulum | IEA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0005886 | Plasma membrane | IEA | cellular_component |
| GO:0005942 | Phosphatidylinositol 3-kinase complex | IBA | cellular_component |
| GO:0006644 | Phospholipid metabolic process | TAS | biological_process |
| GO:0006661 | Phosphatidylinositol biosynthetic process | TAS | biological_process |
| GO:0008150 | Biological_process | ND | biological_process |
| GO:0016301 | Kinase activity | IEA | molecular_function |
| GO:0016303 | 1-phosphatidylinositol-3-kinase activity | IBA | molecular_function |
| GO:0016773 | Phosphotransferase activity, alcohol group as acceptor | IEA | molecular_function |
| GO:0030139 | Endocytic vesicle | IEA | cellular_component |
| GO:0035005 | 1-phosphatidylinositol-4-phosphate 3-kinase activity | NAS | molecular_function |
| GO:0035091 | Phosphatidylinositol binding | IEA | molecular_function |
| GO:0036092 | Phosphatidylinositol-3-phosphate biosynthetic process | IBA | biological_process |
| GO:0043491 | Protein kinase B signaling | IEA | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0046854 | Phosphatidylinositol phosphorylation | IEA | biological_process |
| GO:0048015 | Phosphatidylinositol-mediated signaling | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9607422970 | 0.0051250142 | 0.9999902473 | 0.1459115302 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0001606444 |
| GSE13712_SHEAR | Down | -0.8263024917 |
| GSE13712_STATIC | Down | -0.5813184985 |
| GSE19018 | Down | -1.7857406695 |
| GSE19899_A1 | Down | -0.1737778663 |
| GSE19899_A2 | Down | -1.1567651254 |
| PubMed_21979375_A1 | Down | -1.5734615411 |
| PubMed_21979375_A2 | Down | -0.7838061439 |
| GSE35957 | Down | -0.1766765729 |
| GSE36640 | Up | 0.4725496980 |
| GSE54402 | Down | -1.1445565614 |
| GSE9593 | Down | -0.0655577874 |
| GSE43922 | Down | -0.4445914676 |
| GSE24585 | Down | -0.1981702992 |
| GSE37065 | Down | -0.0208553944 |
| GSE28863_A1 | Up | 0.4392205067 |
| GSE28863_A2 | Up | 0.0712927405 |
| GSE28863_A3 | Down | -0.0212848453 |
| GSE28863_A4 | Up | 0.0867540157 |
| GSE48662 | Down | -0.0207159561 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT018449 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-128-3p | MIMAT0000424 | MIRT022049 | Microarray | Functional MTI (Weak) | 17612493 |
| hsa-miR-15b-5p | MIMAT0000417 | MIRT046415 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
