HCSGD entry for PIK3C2A

1. General information

Official gene symbolPIK3C2A
Entrez ID5286
Gene full namephosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha
Other gene symbolsCPK PI3-K-C2(ALPHA) PI3-K-C2A
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0005524ATP bindingIEAmolecular_function
GO:0005634NucleusIEAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005794Golgi apparatusIEAcellular_component
GO:0005829CytosolTAScellular_component
GO:0005886Plasma membraneIDAcellular_component
GO:0005942Phosphatidylinositol 3-kinase complexIBAcellular_component
GO:0006644Phospholipid metabolic processTASbiological_process
GO:0006661Phosphatidylinositol biosynthetic processTASbiological_process
GO:0006887ExocytosisTASbiological_process
GO:0006897EndocytosisIMPbiological_process
GO:0007173Epidermal growth factor receptor signaling pathwayTASbiological_process
GO:0008286Insulin receptor signaling pathwayTASbiological_process
GO:0014829Vascular smooth muscle contractionTASbiological_process
GO:0016301Kinase activityIEAmolecular_function
GO:00163031-phosphatidylinositol-3-kinase activityIBA IEAmolecular_function
GO:0030136Clathrin-coated vesicleIEAcellular_component
GO:0031982VesicleIDAcellular_component
GO:0035004Phosphatidylinositol 3-kinase activityTASmolecular_function
GO:00350051-phosphatidylinositol-4-phosphate 3-kinase activityTASmolecular_function
GO:0035091Phosphatidylinositol bindingIEAmolecular_function
GO:0044281Small molecule metabolic processTASbiological_process
GO:0046854Phosphatidylinositol phosphorylationIEAbiological_process
GO:0048008Platelet-derived growth factor receptor signaling pathwayTASbiological_process
GO:0048015Phosphatidylinositol-mediated signalingIEAbiological_process
GO:0048268Clathrin coat assemblyTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.12493246460.88708674060.72145704261.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.1797853258
GSE13712_SHEARUp0.1016477981
GSE13712_STATICUp0.0377201417
GSE19018Up0.1044644756
GSE19899_A1Up0.0728599662
GSE19899_A2Up0.2015888697
PubMed_21979375_A1Up0.3337106280
PubMed_21979375_A2Up0.2748991525
GSE35957Up0.3247800614
GSE36640Down-0.0307660911
GSE54402Up0.0700807416
GSE9593Up0.0326737029
GSE43922Up0.1080219840
GSE24585Up0.2519686062
GSE37065Up0.0463468268
GSE28863_A1Up0.3179697581
GSE28863_A2Up0.4866393609
GSE28863_A3Down-1.0584759244
GSE28863_A4Up0.0868371716
GSE48662Down-0.2342050334

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT017588MicroarrayFunctional MTI (Weak)18185580
hsa-miR-124-3pMIMAT0000422MIRT022518MicroarrayFunctional MTI (Weak)18668037
hsa-miR-22-3pMIMAT0000077MIRT030655SequencingFunctional MTI (Weak)20371350
hsa-miR-21-5pMIMAT0000076MIRT030824MicroarrayFunctional MTI (Weak)18591254
hsa-let-7i-5pMIMAT0000415MIRT046552CLASHFunctional MTI (Weak)23622248
hsa-miR-182-5pMIMAT0000259MIRT047215CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.