HCSGD entry for PIGA
1. General information
| Official gene symbol | PIGA |
|---|---|
| Entrez ID | 5277 |
| Gene full name | phosphatidylinositol glycan anchor biosynthesis, class A |
| Other gene symbols | GPI3 MCAHS2 PIG-A |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000506 | Glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex | IDA | cellular_component |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005789 | Endoplasmic reticulum membrane | IDA TAS | cellular_component |
| GO:0006501 | C-terminal protein lipidation | TAS | biological_process |
| GO:0006506 | GPI anchor biosynthetic process | TAS | biological_process |
| GO:0008194 | UDP-glycosyltransferase activity | TAS | molecular_function |
| GO:0009058 | Biosynthetic process | IEA | biological_process |
| GO:0009893 | Positive regulation of metabolic process | TAS | biological_process |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0016254 | Preassembly of GPI anchor in ER membrane | TAS | biological_process |
| GO:0016757 | Transferase activity, transferring glycosyl groups | IEA | molecular_function |
| GO:0017176 | Phosphatidylinositol N-acetylglucosaminyltransferase activity | TAS | molecular_function |
| GO:0043687 | Post-translational protein modification | TAS | biological_process |
| GO:0044267 | Cellular protein metabolic process | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.2349770373 | 0.0320876562 | 0.9180876224 | 0.3371573653 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.6153106220 |
| GSE13712_SHEAR | Down | -0.2947513254 |
| GSE13712_STATIC | Down | -0.3366314476 |
| GSE19018 | Up | 0.2165176919 |
| GSE19899_A1 | Up | 0.2250990352 |
| GSE19899_A2 | Down | -0.2604361430 |
| PubMed_21979375_A1 | Up | 2.2950976854 |
| PubMed_21979375_A2 | Up | 0.0297963148 |
| GSE35957 | Down | -0.9244100661 |
| GSE36640 | Down | -1.5094778152 |
| GSE54402 | Up | 0.7168294110 |
| GSE9593 | Down | -0.5284788123 |
| GSE43922 | Up | 0.0664991873 |
| GSE24585 | Down | -0.7262813543 |
| GSE37065 | Up | 0.2184306456 |
| GSE28863_A1 | Down | -0.1906561280 |
| GSE28863_A2 | Up | 0.5077467214 |
| GSE28863_A3 | Down | -0.6398132247 |
| GSE28863_A4 | Up | 0.3333599867 |
| GSE48662 | Down | -0.1366584386 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-26b-5p | MIMAT0000083 | MIRT028798 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-326 | MIMAT0000756 | MIRT043655 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
