HCSGD entry for SERPINE2

1. General information

Official gene symbolSERPINE2
Entrez ID5270
Gene full nameserpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
Other gene symbolsGDN GDNPF PI-7 PI7 PN-1 PN1 PNI
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0004867Serine-type endopeptidase inhibitor activityIDA IEA IMPmolecular_function
GO:0005102Receptor bindingIEA IPImolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005539Glycosaminoglycan bindingIDAmolecular_function
GO:0005576Extracellular regionIDAcellular_component
GO:0005615Extracellular spaceIBA IEAcellular_component
GO:0005829CytosolIDAcellular_component
GO:0007596Blood coagulationIEAbiological_process
GO:0008201Heparin bindingIDAmolecular_function
GO:0008285Negative regulation of cell proliferationIEAbiological_process
GO:0010544Negative regulation of platelet activationIEAbiological_process
GO:0010757Negative regulation of plasminogen activationIEA IMPbiological_process
GO:0010766Negative regulation of sodium ion transportIEAbiological_process
GO:0010951Negative regulation of endopeptidase activityIBAbiological_process
GO:0010955Negative regulation of protein processingICbiological_process
GO:0014067Negative regulation of phosphatidylinositol 3-kinase signalingIEAbiological_process
GO:0021683Cerebellar granular layer morphogenesisIEAbiological_process
GO:0030195Negative regulation of blood coagulationIC IDAbiological_process
GO:0030308Negative regulation of cell growthIEAbiological_process
GO:0030334Regulation of cell migrationNASbiological_process
GO:0031012Extracellular matrixIDAcellular_component
GO:0031091Platelet alpha granuleIDA IMPcellular_component
GO:0031232Extrinsic component of external side of plasma membraneIDAcellular_component
GO:0031594Neuromuscular junctionIEA ISScellular_component
GO:0032940Secretion by cellIEAbiological_process
GO:0033363Secretory granule organizationIEAbiological_process
GO:0042177Negative regulation of protein catabolic processIEAbiological_process
GO:0042628Mating plug formationIEAbiological_process
GO:0045861Negative regulation of proteolysisIDAbiological_process
GO:0045879Negative regulation of smoothened signaling pathwayIEAbiological_process
GO:0048505Regulation of timing of cell differentiationIEAbiological_process
GO:0048711Positive regulation of astrocyte differentiationIDAbiological_process
GO:0050974Detection of mechanical stimulus involved in sensory perceptionIEAbiological_process
GO:0051966Regulation of synaptic transmission, glutamatergicIEAbiological_process
GO:0060291Long-term synaptic potentiationIEAbiological_process
GO:0060384InnervationIEAbiological_process
GO:0061108Seminal vesicle epithelium developmentIEAbiological_process
GO:0090331Negative regulation of platelet aggregationIEA ISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.00963085370.27671099120.24999378701.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0491774676
GSE13712_SHEARUp1.0212897185
GSE13712_STATICUp1.0172322931
GSE19018Up0.0621500706
GSE19899_A1Up0.7125755203
GSE19899_A2Down-1.0287846387
PubMed_21979375_A1Down-1.3961739146
PubMed_21979375_A2Down-0.8570234836
GSE35957Up0.7653898814
GSE36640Up3.1304651079
GSE54402Down-1.3422113124
GSE9593Up0.3688305193
GSE43922Up0.5560332070
GSE24585Up0.1963056296
GSE37065Up0.3399293497
GSE28863_A1--
GSE28863_A2--
GSE28863_A3--
GSE28863_A4--
GSE48662Down-0.6283559917

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-16-5pMIMAT0000069MIRT001419pSILAC//Proteomics;OtherFunctional MTI (Weak)18668040
hsa-miR-30a-5pMIMAT0000087MIRT028560ProteomicsFunctional MTI (Weak)18668040
hsa-miR-30e-3pMIMAT0000693MIRT044124CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.