HCSGD entry for PI3
1. General information
| Official gene symbol | PI3 |
|---|---|
| Entrez ID | 5266 |
| Gene full name | peptidase inhibitor 3, skin-derived |
| Other gene symbols | ESI SKALP WAP3 WFDC14 cementoin |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004866 | Endopeptidase inhibitor activity | TAS | molecular_function |
| GO:0004867 | Serine-type endopeptidase inhibitor activity | IEA | molecular_function |
| GO:0005578 | Proteinaceous extracellular matrix | TAS | cellular_component |
| GO:0007620 | Copulation | IEA | biological_process |
| GO:0010951 | Negative regulation of endopeptidase activity | TAS | biological_process |
| GO:0052548 | Regulation of endopeptidase activity | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0001744311 | 0.9886679381 | 0.0389084746 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.3904444805 |
| GSE13712_SHEAR | Down | -0.0442523549 |
| GSE13712_STATIC | Up | 0.0617902154 |
| GSE19018 | Up | 0.0948169218 |
| GSE19899_A1 | Up | 0.9433764636 |
| GSE19899_A2 | Up | 4.4311926475 |
| PubMed_21979375_A1 | Up | 6.5438464916 |
| PubMed_21979375_A2 | Up | 3.3570986641 |
| GSE35957 | Up | 0.1281886077 |
| GSE36640 | Up | 0.1314454569 |
| GSE54402 | Up | 7.2465686125 |
| GSE9593 | Up | 0.0289479706 |
| GSE43922 | Up | 1.0031335570 |
| GSE24585 | Down | -0.1783288473 |
| GSE37065 | Up | 1.3521064636 |
| GSE28863_A1 | Down | -0.1435006997 |
| GSE28863_A2 | Up | 0.5818975138 |
| GSE28863_A3 | Up | 0.0359894422 |
| GSE28863_A4 | Up | 0.0803814139 |
| GSE48662 | Down | -0.0649130889 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirTarBase
- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 4 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 22915839 | Invigorating senescent cells with growth factor or snooping with mTOR or PI3 kinase inhibitors compromised cell survival but not senescence |
| 17674777 | In this work, the effect of wortmannin (WM), an inhibitor of PI-3 kinases, including DNA-dependent protein kinase (DNA-PK), on the rejoining of strand breaks in telomeric DNA induced by H2O2 in HeLa cells was examined |
| 15242773 | Selective inhibition of PI3 kinase activity with LY294002 abrogated H2O2-induced cell enlargement and flattened morphology and significantly attenuated the increase in SA-beta-gal activity, but did not affect H2O2-induced cell cycle arrest |
| 9426047 | The signal transduction cascade initiated by the activation of phosphoinositide 3-kinase (PI-3 kinase) is implicated in mitogenic and antiapoptotic signaling generated by growth factors in a variety of cell types |
| 9426047 | We find that a specific PI-3 kinase inhibitor (LY294002) causes growth arrest in these cells accompanied by changes in gene expression that are similar to those seen during cellular senescence |
| 9426047 | The specific phenotypic changes seen following inhibition of PI-3 kinase are: an increase in beta-galactosidase activity; a decrease in EPC-1 gene expression; and a dramatic increase in collagenase gene expression |
| 9426047 | Thus, growth arrest with a PI-3 kinase inhibitor induces a senescent-like phenotype that is not seen when cells are growth arrested by either serum starvation or a MEK-1 inhibitor |
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