HCSGD entry for PHB
1. General information
| Official gene symbol | PHB |
|---|---|
| Entrez ID | 5245 |
| Gene full name | prohibitin |
| Other gene symbols | PHB1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000122 | Negative regulation of transcription from RNA polymerase II promoter | IDA IEA | biological_process |
| GO:0000981 | Sequence-specific DNA binding RNA polymerase II transcription factor activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA IEA TAS | cellular_component |
| GO:0005654 | Nucleoplasm | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005739 | Mitochondrion | IDA | cellular_component |
| GO:0005743 | Mitochondrial inner membrane | IEA TAS | cellular_component |
| GO:0005887 | Integral component of plasma membrane | IDA | cellular_component |
| GO:0006260 | DNA replication | IEA | biological_process |
| GO:0006355 | Regulation of transcription, DNA-templated | IDA | biological_process |
| GO:0007165 | Signal transduction | TAS | biological_process |
| GO:0008285 | Negative regulation of cell proliferation | IMP | biological_process |
| GO:0010944 | Negative regulation of transcription by competitive promoter binding | IDA | biological_process |
| GO:0016020 | Membrane | IEA | cellular_component |
| GO:0016575 | Histone deacetylation | IDA | biological_process |
| GO:0030308 | Negative regulation of cell growth | IMP | biological_process |
| GO:0042826 | Histone deacetylase binding | IPI | molecular_function |
| GO:0042981 | Regulation of apoptotic process | TAS | biological_process |
| GO:0044212 | Transcription regulatory region DNA binding | IDA | molecular_function |
| GO:0045892 | Negative regulation of transcription, DNA-templated | IDA IMP | biological_process |
| GO:0045893 | Positive regulation of transcription, DNA-templated | IDA | biological_process |
| GO:0050847 | Progesterone receptor signaling pathway | IDA | biological_process |
| GO:0060766 | Negative regulation of androgen receptor signaling pathway | IDA IMP | biological_process |
| GO:0071354 | Cellular response to interleukin-6 | IDA | biological_process |
| GO:0071897 | DNA biosynthetic process | IEA | biological_process |
| GO:2000323 | Negative regulation of glucocorticoid receptor signaling pathway | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.3353185403 | 0.4024997986 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.6947390545 |
| GSE13712_SHEAR | Up | 0.2297118551 |
| GSE13712_STATIC | Up | 0.1552746146 |
| GSE19018 | Down | -0.3165498191 |
| GSE19899_A1 | Down | -0.0636712799 |
| GSE19899_A2 | Up | 0.3996944441 |
| PubMed_21979375_A1 | Up | 0.2126422978 |
| PubMed_21979375_A2 | Down | -0.1730470489 |
| GSE35957 | Down | -0.1717561210 |
| GSE36640 | Down | -0.1307586871 |
| GSE54402 | Up | 0.2584996075 |
| GSE9593 | Down | -0.2144959371 |
| GSE43922 | Up | 0.0764780243 |
| GSE24585 | Down | -0.1697688056 |
| GSE37065 | Down | -0.0966552702 |
| GSE28863_A1 | Down | -0.2085938726 |
| GSE28863_A2 | Down | -0.1020088279 |
| GSE28863_A3 | Down | -0.2497477383 |
| GSE28863_A4 | Up | 0.2578352545 |
| GSE48662 | Down | -0.2397389873 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-27a-3p | MIMAT0000084 | MIRT001210 | qRT-PCR//GFP reporter assay//Western blot | Functional MTI | 18789835 |
| hsa-miR-27a-3p | MIMAT0000084 | MIRT001210 | ChIP-seq//Luciferase reporter assay//Northern blot//qRT-PCR//Western blot | Functional MTI | 22505583 |
| hsa-miR-484 | MIMAT0002174 | MIRT041678 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-27a-3p | MIMAT0000084 | 1 | hsa-miR-27a | 18789835 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 10 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 23886751 | These proteins included prohibitin 1, protein disulphide isomerase A3, beta actin, profilin, aldo-ketoreductase 1 C2, alpha crystallin B and the annexins A1, A5 and A6 |
| 21932444 | A total of 13 proteins were up-regulated in CTP, including apoptosis-related cathepsin D (CD), annexin A1 and heat shock protein 27 (HSP 27), and seven proteins were down-regulated in CTP, including prohibitin (PHB) |
| 21932444 | The expression of PHB and CD was confirmed by Western blotting and immunofluorescence staining |
| 21932444 | The abnormal expression of PHB and CD correlated with the generation of reactive oxygen species, leading to decreased mitochondrial membrane potential and telomeric DNA, which are associated with cellular senescence and apoptosis |
| 18195103 | Prohibitin 1 (PHB1) is a highly conserved protein that is mainly localized to the inner mitochondrial membrane and has been implicated in regulating mitochondrial function in yeast |
| 18195103 | Because mitochondria are emerging as an important regulator of vascular homeostasis, we examined PHB1 function in endothelial cells |
| 18195103 | PHB1 is highly expressed in the vascular system and knockdown of PHB1 in endothelial cells increases mitochondrial production of reactive oxygen species via inhibition of complex I, which results in cellular senescence |
| 18195103 | This is also reflected in an in vivo angiogenesis assay, where silencing of PHB1 blocks the formation of functional blood vessels |
| 18195103 | Collectively, our results provide evidence that PHB1 is important for mitochondrial function and prevents reactive oxygen species-induced senescence and thereby maintains the angiogenic capacity of endothelial cells |
| 17427253 | The results are discussed in the context of prohibitin interactions with mitochondrial AAA-proteases and we suggest two possible interaction interfaces between the BAP32:BAP37 building block and the protease |
| 16861898 | This review reflects recent views on the role of some mitochondrial molecular chaperones as prohibitin, mortalin and HSP60/HSP10 complex and their modifications leading to cell transformation and cancer development |
| 16705168 | Prohibitin is a growth regulatory gene that has pleiotropic functions in the nucleus, mitochondria, and cytoplasmic compartments |
| 16705168 | Earlier studies had proposed a role for prohibitin in modulating cellular senescence, but the underlying mechanisms remain unknown |
| 16705168 | Here we show that senescence induced by DNA-damaging agents causes the localization of prohibitin to specific heterochromatic foci |
| 16705168 | Prohibitin could bind to heterochromatin protein 1 (HP1) family proteins and colocalized with HP1gamma in senescence-associated heterochromatic foci |
| 16705168 | Further, HP1gamma could synergize with prohibitin to repress E2F1-mediated transcriptional activity |
| 16705168 | The depletion of prohibitin by small interfering RNA or antisense techniques led to a reduction in the senescent phenotype, correlating with a reduced expression of senescence-associated beta-galactosidase and fewer numbers of senescence-associated heterochromatic foci |
| 16705168 | Chromatin immunoprecipitation assays showed that prohibitin is needed for the recruitment of HP1gamma to E2F1-regulated proliferative promoters, leading to their repression |
| 16705168 | The ablation of prohibitin prevented the recruitment of HPIgamma, but not Suv39H, to the promoters upon senescence |
| 16705168 | Prohibitin-mediated recruitment of HP1gamma occurred in only senescent cells, not in quiescent cells; thus, there is a dichotomy in the recruitment of different corepressors by prohibitin, depending on the type of growth arrest |
| 16705168 | These studies show that prohibitin plays a vital role in inducing cellular senescence |
| 15489194 | Mitochondrial integrity is affected by the PHB1 and PHB2 genes, which encode inner mitochondrial membrane chaperones called prohibitins |
| 15489194 | The Phb1/2 proteins protect the cell from imbalances in the production of mitochondrial proteins |
| 11302691 | Mammalian prohibitin proteins respond to mitochondrial stress and decrease during cellular senescence |
| 11302691 | The two prohibitin proteins, Phb1p and Phb2p(BAP37), have been ascribed various functions, including cell cycle regulation, apoptosis, assembly of mitochondrial respiratory chain enzymes, and aging |
| 9259555 | Another gene postulated to effect senescence is PHB1, the yeast homologue of prohibitin [3], a rodent gene initially identified as a potential regulator of growth arrest and tumour suppressor [6-8] |
| 9259555 | Highly conserved prohibitin homologues have been identified in mammals [9], Drosophila [10], C |
| 9259555 | A second mammalian gene, encoding BAP37, a protein with sequence similarity to prohibitin, is thought to be involved in lymphocyte function [9] |
| 9259555 | Here, we show that the nuclear-encoded mammalian prohibitin and BAP37 proteins are present in mitochondria, are co-expressed, and interact physically with each other |
| 9259555 | Deletion of the Saccharomyces cerevisiae homologues, PHB1 and PHB2, results in a decreased replicative lifespan and a defect in mitochondrial membrane potential |
| 8198603 | Prohibitin expression during cellular senescence of human diploid fibroblasts |
| 8198603 | Prohibitin is an evolutionarily conserved gene postulated to possess tumor suppressor activity and to contribute to the limited lifespan of human diploid fibroblast-like cells |
| 8198603 | Prohibitin mRNA and protein expression and its ability to become post-translationally modified were determined in human diploid fibroblast-like cells of different in vitro ages |
| 8198603 | The expression of prohibitin mRNA and protein changes little with increasing in vitro age; however, its protein product is post-synthetically modified in younger but not older cells |
| 8198603 | These results suggest that prohibitin is similar to the retinoblastoma gene product whose anti-proliferative activity remains active in older cells because it is not post-synthetically modified |
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