HCSGD entry for PGK1
1. General information
| Official gene symbol | PGK1 |
|---|---|
| Entrez ID | 5230 |
| Gene full name | phosphoglycerate kinase 1 |
| Other gene symbols | MIG10 PGKA |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004618 | Phosphoglycerate kinase activity | EXP IEA ISS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA ISS | molecular_function |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0005975 | Carbohydrate metabolic process | TAS | biological_process |
| GO:0006006 | Glucose metabolic process | TAS | biological_process |
| GO:0006094 | Gluconeogenesis | TAS | biological_process |
| GO:0006096 | Glycolysis | IEA TAS | biological_process |
| GO:0016310 | Phosphorylation | ISS | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0372251168 | 0.4442349189 | 0.4364015514 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.8984025047 |
| GSE13712_SHEAR | Up | 0.2360984589 |
| GSE13712_STATIC | Up | 0.1184816963 |
| GSE19018 | Up | 1.8069857481 |
| GSE19899_A1 | Up | 0.2675448596 |
| GSE19899_A2 | Up | 0.0768174865 |
| PubMed_21979375_A1 | Up | 0.1781422279 |
| PubMed_21979375_A2 | Down | -0.0429010323 |
| GSE35957 | Down | -0.3268824240 |
| GSE36640 | Down | -0.7322778231 |
| GSE54402 | Up | 0.0104195541 |
| GSE9593 | Up | 0.0383463630 |
| GSE43922 | Up | 0.0789848944 |
| GSE24585 | Down | -0.3687823128 |
| GSE37065 | Up | 0.0110548952 |
| GSE28863_A1 | Up | 0.2755670746 |
| GSE28863_A2 | Up | 1.2588693930 |
| GSE28863_A3 | Up | 0.1598361630 |
| GSE28863_A4 | Up | 0.0066486801 |
| GSE48662 | Up | 0.1404661785 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Adenosine-5'-[Beta, Gamma-Methylene]Triphosphate | DB03909 | EXPT00416 |
| 3-Phosphoglyceric Acid | DB04510 | EXPT00187 |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-18a-3p | MIMAT0002891 | MIRT040970 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-324-5p | MIMAT0000761 | MIRT043151 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-20a-5p | MIMAT0000075 | MIRT050550 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 2848852 | Cultures derived from a patient with phosphoglycerate kinase I deficiency exhibited reappearance of normal enzyme activity after transformation |
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