HCSGD entry for PFN2
1. General information
| Official gene symbol | PFN2 |
|---|---|
| Entrez ID | 5217 |
| Gene full name | profilin 2 |
| Other gene symbols | D3S1319E PFL |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003779 | Actin binding | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005737 | Cytoplasm | IEA | cellular_component |
| GO:0005856 | Cytoskeleton | IEA | cellular_component |
| GO:0030036 | Actin cytoskeleton organization | IEA | biological_process |
| GO:0030837 | Negative regulation of actin filament polymerization | IEA | biological_process |
| GO:0030838 | Positive regulation of actin filament polymerization | IEA | biological_process |
| GO:0043195 | Terminal bouton | IEA | cellular_component |
| GO:2000300 | Regulation of synaptic vesicle exocytosis | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9574515026 | 0.0112140686 | 0.9999902473 | 0.2091888731 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1803526705 |
| GSE13712_SHEAR | Down | -0.1870322444 |
| GSE13712_STATIC | Up | 0.1584405593 |
| GSE19018 | Up | 0.3334978058 |
| GSE19899_A1 | Down | -0.4898043852 |
| GSE19899_A2 | Down | -0.2715888832 |
| PubMed_21979375_A1 | Down | -1.0320194561 |
| PubMed_21979375_A2 | Down | -0.4557459924 |
| GSE35957 | Down | -0.0273996495 |
| GSE36640 | Up | 0.2890690762 |
| GSE54402 | Down | -0.0724662521 |
| GSE9593 | Up | 0.0224499671 |
| GSE43922 | Down | -0.6053309528 |
| GSE24585 | Down | -0.0323472487 |
| GSE37065 | Down | -0.2692450321 |
| GSE28863_A1 | Down | -0.7946578817 |
| GSE28863_A2 | Down | -0.0606395562 |
| GSE28863_A3 | Down | -1.1257369944 |
| GSE28863_A4 | Down | -0.1684836210 |
| GSE48662 | Down | -0.2206661090 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| 1-Methoxy-2-[2-(2-Methoxy-Ethoxy]-Ethane | DB02078 | EXPT02565 |
| 1-(2-Methoxy-Ethoxy)-2-{2-[2-(2-Methoxy-Ethoxy]-Ethoxy}-Ethane | DB02580 | EXPT02566 |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-7-5p | MIMAT0000252 | MIRT004062 | Microarray//Microarray;Other | Functional MTI (Weak) | 19073608 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT029555 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-100-5p | MIMAT0000098 | MIRT048419 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
