HCSGD entry for PFN1
1. General information
| Official gene symbol | PFN1 |
|---|---|
| Entrez ID | 5216 |
| Gene full name | profilin 1 |
| Other gene symbols | ALS18 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001843 | Neural tube closure | IEA | biological_process |
| GO:0002576 | Platelet degranulation | TAS | biological_process |
| GO:0003779 | Actin binding | IEA IPI | molecular_function |
| GO:0005102 | Receptor binding | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005546 | Phosphatidylinositol-4,5-bisphosphate binding | IEA | molecular_function |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0005737 | Cytoplasm | IEA | cellular_component |
| GO:0005856 | Cytoskeleton | IEA | cellular_component |
| GO:0007596 | Blood coagulation | TAS | biological_process |
| GO:0008219 | Cell death | IEA | biological_process |
| GO:0017048 | Rho GTPase binding | IEA | molecular_function |
| GO:0030036 | Actin cytoskeleton organization | IEA | biological_process |
| GO:0030168 | Platelet activation | TAS | biological_process |
| GO:0043005 | Neuron projection | IEA | cellular_component |
| GO:0045202 | Synapse | IEA | cellular_component |
| GO:0045944 | Positive regulation of transcription from RNA polymerase II promoter | IEA | biological_process |
| GO:0050434 | Positive regulation of viral transcription | IEA | biological_process |
| GO:0051054 | Positive regulation of DNA metabolic process | IEA | biological_process |
| GO:0051496 | Positive regulation of stress fiber assembly | IEA | biological_process |
| GO:0070064 | Proline-rich region binding | IPI | molecular_function |
| GO:0071363 | Cellular response to growth factor stimulus | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.7286947266 | 0.5099202310 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0031727863 |
| GSE13712_SHEAR | Up | 0.3195358690 |
| GSE13712_STATIC | Down | -0.0188911083 |
| GSE19018 | Up | 0.0484371872 |
| GSE19899_A1 | Down | -0.0798333109 |
| GSE19899_A2 | Up | 0.2931852265 |
| PubMed_21979375_A1 | Up | 0.2198079667 |
| PubMed_21979375_A2 | Down | -0.0217546228 |
| GSE35957 | Down | -0.2897218198 |
| GSE36640 | Down | -0.1234720451 |
| GSE54402 | Up | 0.1368150399 |
| GSE9593 | Down | -0.1619862348 |
| GSE43922 | Up | 0.0840128094 |
| GSE24585 | Down | -0.1378244841 |
| GSE37065 | Down | -0.1180174315 |
| GSE28863_A1 | Up | 0.0749872654 |
| GSE28863_A2 | Down | -0.1473772984 |
| GSE28863_A3 | Up | 0.0041619382 |
| GSE28863_A4 | Up | 0.0608961702 |
| GSE48662 | Down | -0.1339404374 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| 7-HYDROXY-4-METHYL-3-(2-HYDROXY-ETHYL)COUMARIN | DB07908 | - |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-182-5p | MIMAT0000259 | MIRT007199 | Luciferase reporter assay | Functional MTI | 23430586 |
| hsa-miR-941 | MIMAT0004984 | MIRT036585 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-99b-3p | MIMAT0004678 | MIRT038531 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-766-3p | MIMAT0003888 | MIRT039051 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92b-3p | MIMAT0003218 | MIRT040578 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-193b-3p | MIMAT0002819 | MIRT041589 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-222-3p | MIMAT0000279 | MIRT046707 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-30c-5p | MIMAT0000244 | MIRT047929 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049148 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7b-5p | MIMAT0000063 | MIRT051906 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 19826041 | We observed dramatic cytoskeletal reorganization of hMSC through reduction of myosin-10, redistribution of myosin-9, and secretion of profilin-1 |
| 17550585 | SELDI-TOF-MS ProteinChip array profiling of T-cell clones propagated in long-term culture identifies human profilin-1 as a potential bio-marker of immunosenescence |
| 17550585 | Human profilin-1, a ubiquitous protein associated with actin remodelling and cellular motility was unambiguously identified |
| 17550585 | Altered expression of profilin-1 in senescent T-cell clones was confirmed by Western blot analysis |
| 17550585 | CONCLUSION: Due to the proposed roles of profilin-1 in cellular survival, cytoskeleton remodelling, motility, and proliferation, it is hypothesised that differential expression of profilin-1 in ageing may contribute directly to immunosenescence |
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