HCSGD entry for PFKM
1. General information
| Official gene symbol | PFKM |
|---|---|
| Entrez ID | 5213 |
| Gene full name | phosphofructokinase, muscle |
| Other gene symbols | GSD7 PFK-1 PFK1 PFKA PFKX |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003872 | 6-phosphofructokinase activity | IDA IEA IMP ISS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IDA | molecular_function |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0005945 | 6-phosphofructokinase complex | IDA IEA | cellular_component |
| GO:0005975 | Carbohydrate metabolic process | TAS | biological_process |
| GO:0006002 | Fructose 6-phosphate metabolic process | IDA IEA IMP | biological_process |
| GO:0006006 | Glucose metabolic process | TAS | biological_process |
| GO:0006096 | Glycolysis | IEA IMP TAS | biological_process |
| GO:0008022 | Protein C-terminus binding | IPI | molecular_function |
| GO:0016324 | Apical plasma membrane | IDA | cellular_component |
| GO:0019900 | Kinase binding | IPI | molecular_function |
| GO:0032024 | Positive regulation of insulin secretion | IEA | biological_process |
| GO:0042593 | Glucose homeostasis | IEA | biological_process |
| GO:0042802 | Identical protein binding | IPI | molecular_function |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0046716 | Muscle cell cellular homeostasis | IMP | biological_process |
| GO:0046835 | Carbohydrate phosphorylation | IDA IMP ISS | biological_process |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
| GO:0051259 | Protein oligomerization | IDA | biological_process |
| GO:0070061 | Fructose binding | IDA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1033262946 | 0.6819066867 | 0.6687119253 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.8886388351 |
| GSE13712_SHEAR | Down | -0.2018938290 |
| GSE13712_STATIC | Down | -0.1015180474 |
| GSE19018 | Up | 0.3769903612 |
| GSE19899_A1 | Up | 0.3486780816 |
| GSE19899_A2 | Up | 0.4292022395 |
| PubMed_21979375_A1 | Down | -0.6951119986 |
| PubMed_21979375_A2 | Up | 0.5486150007 |
| GSE35957 | Down | -0.1967698060 |
| GSE36640 | Up | 0.3277356431 |
| GSE54402 | Up | 0.1847596156 |
| GSE9593 | Up | 0.1867941143 |
| GSE43922 | Down | -0.0128548218 |
| GSE24585 | Down | -0.0991288983 |
| GSE37065 | Up | 0.0630756140 |
| GSE28863_A1 | Down | -0.0606170815 |
| GSE28863_A2 | Up | 0.2103347252 |
| GSE28863_A3 | Down | -0.6641883102 |
| GSE28863_A4 | Up | 0.0603169354 |
| GSE48662 | Up | 0.0037916661 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-320a | MIMAT0000510 | MIRT044562 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049227 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7b-5p | MIMAT0000063 | MIRT052269 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
