HCSGD entry for PFKFB2
1. General information
| Official gene symbol | PFKFB2 |
|---|---|
| Entrez ID | 5208 |
| Gene full name | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 |
| Other gene symbols | PFK-2/FBPase-2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003873 | 6-phosphofructo-2-kinase activity | IDA IEA | molecular_function |
| GO:0004331 | Fructose-2,6-bisphosphate 2-phosphatase activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005737 | Cytoplasm | IEA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0005975 | Carbohydrate metabolic process | TAS | biological_process |
| GO:0006000 | Fructose metabolic process | IEA | biological_process |
| GO:0006003 | Fructose 2,6-bisphosphate metabolic process | IEA | biological_process |
| GO:0006006 | Glucose metabolic process | TAS | biological_process |
| GO:0006007 | Glucose catabolic process | IEA | biological_process |
| GO:0006089 | Lactate metabolic process | IEA | biological_process |
| GO:0006090 | Pyruvate metabolic process | IEA | biological_process |
| GO:0006096 | Glycolysis | IDA TAS | biological_process |
| GO:0009749 | Response to glucose | IEA | biological_process |
| GO:0019900 | Kinase binding | IEA | molecular_function |
| GO:0019901 | Protein kinase binding | IPI | molecular_function |
| GO:0032024 | Positive regulation of insulin secretion | IEA | biological_process |
| GO:0033133 | Positive regulation of glucokinase activity | IEA | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0046835 | Carbohydrate phosphorylation | IDA TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1717333536 | 0.9456138711 | 0.8141753013 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0196535642 |
| GSE13712_SHEAR | Down | -0.1701723430 |
| GSE13712_STATIC | Down | -0.0318143371 |
| GSE19018 | Up | 0.1276164248 |
| GSE19899_A1 | Down | -0.0277158858 |
| GSE19899_A2 | Up | 0.1118641793 |
| PubMed_21979375_A1 | Down | -0.2084296087 |
| PubMed_21979375_A2 | Up | 0.1041865040 |
| GSE35957 | Up | 0.4782988365 |
| GSE36640 | Up | 0.4384211056 |
| GSE54402 | Down | -0.0554483524 |
| GSE9593 | Up | 0.1761778896 |
| GSE43922 | Up | 0.0124957227 |
| GSE24585 | Up | 0.5896828910 |
| GSE37065 | Up | 0.1999592884 |
| GSE28863_A1 | Up | 0.1446567719 |
| GSE28863_A2 | Up | 0.3884182203 |
| GSE28863_A3 | Up | 0.1932995954 |
| GSE28863_A4 | Down | -0.1443449824 |
| GSE48662 | Up | 0.1014966127 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-122-5p | MIMAT0000421 | MIRT023270 | Microarray | Functional MTI (Weak) | 17612493 |
| hsa-miR-21-5p | MIMAT0000076 | MIRT030745 | Microarray | Functional MTI (Weak) | 18591254 |
| hsa-miR-181a-5p | MIMAT0000256 | MIRT047308 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
