HCSGD entry for PFKFB1

1. General information

Official gene symbolPFKFB1
Entrez ID5207
Gene full name6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
Other gene symbolsF6PK HL2K PFRX
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:00038736-phosphofructo-2-kinase activityIEA TASmolecular_function
GO:0004331Fructose-2,6-bisphosphate 2-phosphatase activityIDA IEA TASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005829CytosolTAScellular_component
GO:0005975Carbohydrate metabolic processTASbiological_process
GO:0006000Fructose metabolic processIEAbiological_process
GO:0006003Fructose 2,6-bisphosphate metabolic processIDA IEAbiological_process
GO:0006006Glucose metabolic processTASbiological_process
GO:0006094GluconeogenesisTASbiological_process
GO:0006096GlycolysisTASbiological_process
GO:0006112Energy reserve metabolic processTASbiological_process
GO:0016311DephosphorylationIDA TASbiological_process
GO:0019900Kinase bindingIEAmolecular_function
GO:0031100Organ regenerationIEAbiological_process
GO:0032868Response to insulinIEAbiological_process
GO:0033133Positive regulation of glucokinase activityIEAbiological_process
GO:0033762Response to glucagonIEAbiological_process
GO:0042594Response to starvationIEAbiological_process
GO:0042802Identical protein bindingIEAmolecular_function
GO:00435406-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 complexIDAcellular_component
GO:0044281Small molecule metabolic processTASbiological_process
GO:0051384Response to glucocorticoidIEAbiological_process
GO:0051591Response to cAMPIEAbiological_process
GO:0070095Fructose-6-phosphate bindingIEAmolecular_function
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.74470657650.79975446600.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0680908925
GSE13712_SHEARDown-0.0605120717
GSE13712_STATICDown-0.0850122695
GSE19018Up0.0697013361
GSE19899_A1Up0.0322887846
GSE19899_A2Up0.0280968984
PubMed_21979375_A1Up0.1492759801
PubMed_21979375_A2Up0.1140343034
GSE35957Up0.1959529886
GSE36640Up0.0934078280
GSE54402Up0.0448127280
GSE9593Down-0.1251259228
GSE43922Up0.0129987736
GSE24585Down-0.2821798047
GSE37065Up0.0106903580
GSE28863_A1Up0.1217597700
GSE28863_A2Up0.0592544440
GSE28863_A3Up0.1306363237
GSE28863_A4Down-0.0434624747
GSE48662Up0.1561628697

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

D-Gluco-2,5-Anhydro-1-Deoxy-1-Phosphonohexitol-6-PhosphateDB02393 EXPT01415
3-PhosphoglycerolDB02515 EXPT01531
Phosphothiophosphoric Acid-Adenylate EsterDB02930 EXPT00458
Guanosine-5'-TriphosphateDB04137 EXPT01660
Fructose-6-PhosphateDB04493 EXPT01383

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.