HCSGD entry for POLR3K

1. General information

Official gene symbolPOLR3K
Entrez ID51728
Gene full namepolymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa
Other gene symbolsC11 C11-RNP3 RPC10 RPC11 RPC12.5 hRPC11
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001056RNA polymerase III activityIBAmolecular_function
GO:0003677DNA bindingIEAmolecular_function
GO:0003899DNA-directed RNA polymerase activityTASmolecular_function
GO:0005654NucleoplasmTAScellular_component
GO:0005666DNA-directed RNA polymerase III complexIBAcellular_component
GO:0005829CytosolTAScellular_component
GO:0006383Transcription from RNA polymerase III promoterTASbiological_process
GO:0006385Transcription elongation from RNA polymerase III promoterTASbiological_process
GO:0006386Termination of RNA polymerase III transcriptionIBA TASbiological_process
GO:0008270Zinc ion bindingIEAmolecular_function
GO:0010467Gene expressionTASbiological_process
GO:0032481Positive regulation of type I interferon productionTASbiological_process
GO:0045087Innate immune responseTASbiological_process
GO:0051607Defense response to virusIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.40167439310.34598949890.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.4289015093
GSE13712_SHEARUp0.1552622360
GSE13712_STATICUp0.0568093767
GSE19018Up0.1186933529
GSE19899_A1Down-0.1419299068
GSE19899_A2Down-0.0280169656
PubMed_21979375_A1Up0.2024637935
PubMed_21979375_A2Down-0.2591638144
GSE35957Down-0.3516068417
GSE36640Down-0.1635923238
GSE54402Up0.3644361141
GSE9593Down-0.2291876353
GSE43922Up0.0431562983
GSE24585Down-0.6123678096
GSE37065Up0.2481251330
GSE28863_A1Down-0.1538549815
GSE28863_A2Down-0.0128332576
GSE28863_A3Up0.1016020906
GSE28863_A4Up0.1924531744
GSE48662Down-0.1921104403

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-484MIMAT0002174MIRT041912CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.