HCSGD entry for PDPK1
1. General information
| Official gene symbol | PDPK1 |
|---|---|
| Entrez ID | 5170 |
| Gene full name | 3-phosphoinositide dependent protein kinase-1 |
| Other gene symbols | PDK1 PDPK2 PRO0461 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003323 | Type B pancreatic cell development | IEA | biological_process |
| GO:0004672 | Protein kinase activity | IEA | molecular_function |
| GO:0004674 | Protein serine/threonine kinase activity | IDA IEA TAS | molecular_function |
| GO:0004676 | 3-phosphoinositide-dependent protein kinase activity | IDA IEA | molecular_function |
| GO:0005158 | Insulin receptor binding | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005829 | Cytosol | IEA TAS | cellular_component |
| GO:0005886 | Plasma membrane | IDA IEA TAS | cellular_component |
| GO:0005925 | Focal adhesion | IEA | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0006355 | Regulation of transcription, DNA-templated | IEA | biological_process |
| GO:0006468 | Protein phosphorylation | IDA | biological_process |
| GO:0006469 | Negative regulation of protein kinase activity | IDA | biological_process |
| GO:0006972 | Hyperosmotic response | IEA | biological_process |
| GO:0007173 | Epidermal growth factor receptor signaling pathway | TAS | biological_process |
| GO:0007268 | Synaptic transmission | TAS | biological_process |
| GO:0007596 | Blood coagulation | TAS | biological_process |
| GO:0008286 | Insulin receptor signaling pathway | TAS | biological_process |
| GO:0008543 | Fibroblast growth factor receptor signaling pathway | TAS | biological_process |
| GO:0010594 | Regulation of endothelial cell migration | IEA | biological_process |
| GO:0010667 | Negative regulation of cardiac muscle cell apoptotic process | IEA | biological_process |
| GO:0016023 | Cytoplasmic membrane-bounded vesicle | IEA | cellular_component |
| GO:0016301 | Kinase activity | EXP | molecular_function |
| GO:0018107 | Peptidyl-threonine phosphorylation | IDA | biological_process |
| GO:0019901 | Protein kinase binding | IEA | molecular_function |
| GO:0030036 | Actin cytoskeleton organization | TAS | biological_process |
| GO:0030168 | Platelet activation | TAS | biological_process |
| GO:0030512 | Negative regulation of transforming growth factor beta receptor signaling pathway | IDA | biological_process |
| GO:0031295 | T cell costimulation | TAS | biological_process |
| GO:0032148 | Activation of protein kinase B activity | IDA | biological_process |
| GO:0032869 | Cellular response to insulin stimulus | IMP | biological_process |
| GO:0034122 | Negative regulation of toll-like receptor signaling pathway | IEA | biological_process |
| GO:0035556 | Intracellular signal transduction | IDA | biological_process |
| GO:0038095 | Fc-epsilon receptor signaling pathway | TAS | biological_process |
| GO:0043122 | Regulation of I-kappaB kinase/NF-kappaB signaling | IMP | biological_process |
| GO:0043304 | Regulation of mast cell degranulation | IEA | biological_process |
| GO:0045087 | Innate immune response | TAS | biological_process |
| GO:0046777 | Protein autophosphorylation | TAS | biological_process |
| GO:0048011 | Neurotrophin TRK receptor signaling pathway | TAS | biological_process |
| GO:0048015 | Phosphatidylinositol-mediated signaling | TAS | biological_process |
| GO:0048041 | Focal adhesion assembly | IEA | biological_process |
| GO:0050852 | T cell receptor signaling pathway | TAS | biological_process |
| GO:0090004 | Positive regulation of establishment of protein localization to plasma membrane | IMP | biological_process |
| GO:0097191 | Extrinsic apoptotic signaling pathway | IMP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0374685954 | 0.9894891380 | 0.4369565352 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0292600340 |
| GSE13712_SHEAR | Up | 0.1401696052 |
| GSE13712_STATIC | Up | 0.1493621690 |
| GSE19018 | Down | -0.0089206624 |
| GSE19899_A1 | Up | 0.3396931400 |
| GSE19899_A2 | Up | 0.6231653264 |
| PubMed_21979375_A1 | Up | 0.5281133336 |
| PubMed_21979375_A2 | Up | 0.6254898470 |
| GSE35957 | Up | 0.2652889889 |
| GSE36640 | Up | 0.6213111103 |
| GSE54402 | Up | 0.0938006796 |
| GSE9593 | Up | 0.1884875431 |
| GSE43922 | Up | 0.2574307713 |
| GSE24585 | Down | -0.0561982044 |
| GSE37065 | Up | 0.0421041765 |
| GSE28863_A1 | Up | 0.3578496895 |
| GSE28863_A2 | Down | -0.0106449389 |
| GSE28863_A3 | Up | 0.1312143055 |
| GSE28863_A4 | Up | 0.1602182474 |
| GSE48662 | Down | -0.1334054815 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
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- Drugs
Name | Drug | Accession number |
|---|---|---|
| Celecoxib | DB00482 | APRD00373 |
| Inositol 1,3,4,5-Tetrakisphosphate | DB01863 | EXPT01943 | DB03265 |
| 7-Hydroxystaurosporine | DB01933 | EXPT03167 |
| 3-[1-(3-Aminopropyl)-1h-Indol-3-Yl]-4-(1-Methyl-1h-Indol-3-Yl)-1h-Pyrrole-2,5-Dione | DB01946 | EXPT00704 |
| Staurosporine | DB02010 | EXPT02970 | EXPT02972 |
| Rbt205 Inhibitor | DB03777 | EXPT00703 |
| Phosphonoserine | DB04522 | EXPT02883 |
| 10,11-dimethoxy-4-methyldibenzo[c,f]-2,7-naphthyridine-3,6-diamine | DB06932 | - |
| 5-HYDROXY-3-[(1R)-1-(1H-PYRROL-2-YL)ETHYL]-2H-INDOL-2-ONE | DB07033 | - |
| 1-{2-OXO-3-[(1R)-1-(1H-PYRROL-2-YL)ETHYL]-2H-INDOL-5-YL}UREA | DB07132 | - |
| 2-(1H-imidazol-1-yl)-9-methoxy-8-(2-methoxyethoxy)benzo[c][2,7]naphthyridin-4-amine | DB07300 | - |
| 3-(1H-INDOL-3-YL)-4-(1-{2-[(2S)-1-METHYLPYRROLIDINYL]ETHYL}-1H-INDOL-3-YL)-1H-PYRROLE-2,5-DIONE | DB07456 | - |
| 3-[1-(3-AMINOPROPYL)-1H-INDOL-3-YL]-4-(1H-INDOL-3-YL)-1H-PYRROLE-2,5-DIONE | DB07457 | - |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-125a-5p | MIMAT0000443 | MIRT021308 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-128-3p | MIMAT0000424 | MIRT021893 | Microarray | Functional MTI (Weak) | 17612493 |
| hsa-miR-10a-5p | MIMAT0000253 | MIRT025610 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-24-3p | MIMAT0000080 | MIRT030439 | Microarray | Functional MTI (Weak) | 19748357 |
| hsa-miR-744-5p | MIMAT0004945 | MIRT037453 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-423-5p | MIMAT0004748 | MIRT038100 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-331-3p | MIMAT0000760 | MIRT043522 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-185-5p | MIMAT0000455 | MIRT045314 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-17-5p | MIMAT0000070 | MIRT051003 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 24213576 | Decreased p-AKT activity results from repression of integrin-linked kinase (ILK) and phosphoinositide-dependent protein kinase-1 (PDPK1) expression |
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