HCSGD entry for CPSF3
1. General information
| Official gene symbol | CPSF3 |
|---|---|
| Entrez ID | 51692 |
| Gene full name | cleavage and polyadenylation specific factor 3, 73kDa |
| Other gene symbols | CPSF-73 CPSF73 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000398 | MRNA splicing, via spliceosome | TAS | biological_process |
| GO:0003723 | RNA binding | IEA ISS | molecular_function |
| GO:0004521 | Endoribonuclease activity | IEA ISS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0005847 | MRNA cleavage and polyadenylation specificity factor complex | IDA | cellular_component |
| GO:0006366 | Transcription from RNA polymerase II promoter | TAS | biological_process |
| GO:0006369 | Termination of RNA polymerase II transcription | TAS | biological_process |
| GO:0006378 | MRNA polyadenylation | TAS | biological_process |
| GO:0006379 | MRNA cleavage | TAS | biological_process |
| GO:0006398 | Histone mRNA 3'-end processing | IDA | biological_process |
| GO:0006406 | MRNA export from nucleus | TAS | biological_process |
| GO:0008380 | RNA splicing | TAS | biological_process |
| GO:0008409 | 5'-3' exonuclease activity | IEA ISS | molecular_function |
| GO:0010467 | Gene expression | TAS | biological_process |
| GO:0030529 | Ribonucleoprotein complex | IEA | cellular_component |
| GO:0031124 | MRNA 3'-end processing | TAS | biological_process |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
| GO:0090501 | RNA phosphodiester bond hydrolysis | ISS | biological_process |
| GO:0090502 | RNA phosphodiester bond hydrolysis, endonucleolytic | ISS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.8462331712 | 0.0394374644 | 0.9999902473 | 0.3746060989 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.4996015301 |
| GSE13712_SHEAR | Down | -0.2879391699 |
| GSE13712_STATIC | Down | -0.1078685712 |
| GSE19018 | Up | 0.0475706453 |
| GSE19899_A1 | Down | -0.2582686751 |
| GSE19899_A2 | Down | -0.3964630245 |
| PubMed_21979375_A1 | Down | -0.1712971543 |
| PubMed_21979375_A2 | Down | -0.7756944965 |
| GSE35957 | Down | -0.0936784044 |
| GSE36640 | Down | -0.9643827137 |
| GSE54402 | Down | -0.1584989101 |
| GSE9593 | Down | -0.4555795496 |
| GSE43922 | Down | -0.0158932988 |
| GSE24585 | Down | -0.4240301726 |
| GSE37065 | Up | 0.1321720278 |
| GSE28863_A1 | Up | 0.3415488368 |
| GSE28863_A2 | Up | 0.8232198651 |
| GSE28863_A3 | Down | -0.2061246386 |
| GSE28863_A4 | Down | -0.2498905836 |
| GSE48662 | Down | -0.4320574778 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-1 | MIMAT0000416 | MIRT023534 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-30a-5p | MIMAT0000087 | MIRT028443 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-708-5p | MIMAT0004926 | MIRT037757 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
