HCSGD entry for ENPP3
1. General information
| Official gene symbol | ENPP3 |
|---|---|
| Entrez ID | 5169 |
| Gene full name | ectonucleotide pyrophosphatase/phosphodiesterase 3 |
| Other gene symbols | B10 CD203c NPP3 PD-IBETA PDNP3 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003676 | Nucleic acid binding | IEA | molecular_function |
| GO:0003824 | Catalytic activity | IEA | molecular_function |
| GO:0004528 | Phosphodiesterase I activity | IEA | molecular_function |
| GO:0004551 | Nucleotide diphosphatase activity | TAS | molecular_function |
| GO:0005044 | Scavenger receptor activity | IEA | molecular_function |
| GO:0005576 | Extracellular region | IEA | cellular_component |
| GO:0005887 | Integral component of plasma membrane | TAS | cellular_component |
| GO:0006796 | Phosphate-containing compound metabolic process | IDA | biological_process |
| GO:0006955 | Immune response | IEA | biological_process |
| GO:0009143 | Nucleoside triphosphate catabolic process | IDA | biological_process |
| GO:0030247 | Polysaccharide binding | IEA | molecular_function |
| GO:0030505 | Inorganic diphosphate transport | IDA | biological_process |
| GO:0035529 | NADH pyrophosphatase activity | IEA | molecular_function |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
| GO:0047429 | Nucleoside-triphosphate diphosphatase activity | IDA | molecular_function |
| GO:0048471 | Perinuclear region of cytoplasm | IDA | cellular_component |
| GO:0090305 | Nucleic acid phosphodiester bond hydrolysis | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.4706630751 | 0.9241793891 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1486739785 |
| GSE13712_SHEAR | Down | -0.0783611501 |
| GSE13712_STATIC | Down | -0.0537397730 |
| GSE19018 | Up | 0.0702937595 |
| GSE19899_A1 | Up | 0.0935187092 |
| GSE19899_A2 | Up | 0.0605084969 |
| PubMed_21979375_A1 | Up | 0.1047700166 |
| PubMed_21979375_A2 | Up | 0.1115002561 |
| GSE35957 | Up | 0.0043737150 |
| GSE36640 | Down | -0.0565692807 |
| GSE54402 | Up | 0.0456635482 |
| GSE9593 | Down | -0.1628779482 |
| GSE43922 | Up | 0.0406559956 |
| GSE24585 | Up | 0.5638493912 |
| GSE37065 | Up | 0.0502891725 |
| GSE28863_A1 | Up | 0.0520925638 |
| GSE28863_A2 | Up | 0.0432515930 |
| GSE28863_A3 | Down | -0.0126263466 |
| GSE28863_A4 | Down | -0.0653426819 |
| GSE48662 | Up | 0.1408566570 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirTarBase
- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 19841470 | After having identified prosenescent and proapoptotic doses of epirubicin and rat MAb c-erbB2/Her-2/neu Ab-9 clone B10 (B10), an anti-erbB2 monoclonal antibody, we investigated the effects of the sequential treatment with prosenescent doses of both drugs on H9c2 cells and neonatal rat cardiomyocytes pretreated with or without the cardioprotective agent dexrazoxane |
| 19841470 | Data demonstrate that 1) the toxic effects of epirubicin mainly occur through NAD(P)H oxidase activation; 2) the erbB2 overexpression induced by epirubicin is a redox-sensitive mechanism largely dependent on NAD(P)H oxidase; 3) the loss of erbB2-related functions caused by B10 determines marginal cellular changes in untreated cells, but causes massive death by apoptosis in cells previously exposed to a prosenescent dose of epirubicin, 4) dexrazoxane promotes survival pathways, as demonstrated by the activation of Akt and the PI3K-dependent erbB2 overexpression; and 5) it also prevents epirubicin-induced senescence and renders epirubicin-treated cells more resistant to treatment with B10 |
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