HCSGD entry for PDK4

1. General information

Official gene symbolPDK4
Entrez ID5166
Gene full namepyruvate dehydrogenase kinase, isozyme 4
Other gene symbols
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0004672Protein kinase activityIDAmolecular_function
GO:0004674Protein serine/threonine kinase activityIEAmolecular_function
GO:0004740Pyruvate dehydrogenase (acetyl-transferring) kinase activityISSmolecular_function
GO:0005524ATP bindingIDAmolecular_function
GO:0005739MitochondrionTAScellular_component
GO:0005743Mitochondrial inner membraneIEAcellular_component
GO:0005759Mitochondrial matrixTAScellular_component
GO:0006006Glucose metabolic processIEAbiological_process
GO:0006090Pyruvate metabolic processTASbiological_process
GO:0006468Protein phosphorylationIDA ISS TASbiological_process
GO:0006885Regulation of pHISSbiological_process
GO:0008286Insulin receptor signaling pathwayIMPbiological_process
GO:0009267Cellular response to starvationIDAbiological_process
GO:0010510Regulation of acetyl-CoA biosynthetic process from pyruvateIMP TASbiological_process
GO:0010565Regulation of cellular ketone metabolic processISSbiological_process
GO:0010906Regulation of glucose metabolic processIMPbiological_process
GO:0042304Regulation of fatty acid biosynthetic processIMPbiological_process
GO:0042593Glucose homeostasisISSbiological_process
GO:0042594Response to starvationISSbiological_process
GO:0044237Cellular metabolic processTASbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0045124Regulation of bone resorptionIEAbiological_process
GO:0046320Regulation of fatty acid oxidationISSbiological_process
GO:0071398Cellular response to fatty acidIMPbiological_process
GO:0072593Reactive oxygen species metabolic processIMPbiological_process
GO:2000811Negative regulation of anoikisIMPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.00094372930.80292656430.08363602691.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up1.2671620820
GSE13712_SHEARDown-1.0779552544
GSE13712_STATICDown-0.9101857134
GSE19018Up0.0101588133
GSE19899_A1Up0.5463950867
GSE19899_A2Up1.5353335598
PubMed_21979375_A1Up1.1759060778
PubMed_21979375_A2Up0.3324082240
GSE35957Down-0.4498383298
GSE36640Up0.4351904382
GSE54402Up0.8303191679
GSE9593Up0.2880658420
GSE43922Up0.3455228143
GSE24585Up0.5794596029
GSE37065Up0.4381072441
GSE28863_A1Up1.0187088413
GSE28863_A2Up1.7939501120
GSE28863_A3Up0.1221496978
GSE28863_A4Down-0.2065733574
GSE48662Up0.0363611470

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

4-[4-(4-methoxyphenyl)-5-methyl-1H-pyrazol-3-yl]benzene-1,3-diolDB08356 -

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT018910MicroarrayFunctional MTI (Weak)18185580
hsa-miR-103a-3pMIMAT0000101MIRT027229SequencingFunctional MTI (Weak)20371350
hsa-miR-26b-5pMIMAT0000083MIRT030098MicroarrayFunctional MTI (Weak)19088304
hsa-miR-16-5pMIMAT0000069MIRT032003SequencingFunctional MTI (Weak)20371350
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.