HCSGD entry for PDE6B

1. General information

Official gene symbolPDE6B
Entrez ID5158
Gene full namephosphodiesterase 6B, cGMP-specific, rod, beta
Other gene symbolsCSNB3 CSNBAD2 PDEB RP40 rd1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:00041143',5'-cyclic-nucleotide phosphodiesterase activityIEAmolecular_function
GO:0007165Signal transductionIEAbiological_process
GO:0007596Blood coagulationTASbiological_process
GO:0007601Visual perceptionIEAbiological_process
GO:0007603Phototransduction, visible lightTASbiological_process
GO:0009583Detection of light stimulusIEAbiological_process
GO:0016056Rhodopsin mediated signaling pathwayTASbiological_process
GO:0022400Regulation of rhodopsin mediated signaling pathwayTASbiological_process
GO:0046037GMP metabolic processIMPbiological_process
GO:0046872Metal ion bindingIEAmolecular_function
GO:00475553',5'-cyclic-GMP phosphodiesterase activityIMPmolecular_function
GO:0051480Cytosolic calcium ion homeostasisIMPbiological_process
GO:0060041Retina development in camera-type eyeIEAbiological_process
GO:0097381Photoreceptor disc membraneTAScellular_component
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.49075927210.82990112840.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0421251187
GSE13712_SHEARDown-0.0141121816
GSE13712_STATICUp0.2651126221
GSE19018Up0.1160641636
GSE19899_A1Down-0.0454043203
GSE19899_A2Up0.1897591429
PubMed_21979375_A1Up0.2168191618
PubMed_21979375_A2Up0.0375724308
GSE35957Up0.1394921646
GSE36640Up0.0678072786
GSE54402Up0.0414891103
GSE9593Down-0.0153886309
GSE43922Up0.0302381611
GSE24585Up0.2358209779
GSE37065Down-0.1527844610
GSE28863_A1Down-0.0460228299
GSE28863_A2Down-0.1184721043
GSE28863_A3Up0.3729072379
GSE28863_A4Down-0.0868531234
GSE48662Down-0.0949637285

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.