HCSGD entry for HDAC7
1. General information
| Official gene symbol | HDAC7 |
|---|---|
| Entrez ID | 51564 |
| Gene full name | histone deacetylase 7 |
| Other gene symbols | HD7A HDAC7A |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000118 | Histone deacetylase complex | IEA | cellular_component |
| GO:0000122 | Negative regulation of transcription from RNA polymerase II promoter | IEA | biological_process |
| GO:0001570 | Vasculogenesis | IEA | biological_process |
| GO:0003682 | Chromatin binding | IEA | molecular_function |
| GO:0003714 | Transcription corepressor activity | IEA | molecular_function |
| GO:0004407 | Histone deacetylase activity | IEA | molecular_function |
| GO:0005080 | Protein kinase C binding | IPI | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0007043 | Cell-cell junction assembly | IEA | biological_process |
| GO:0007219 | Notch signaling pathway | TAS | biological_process |
| GO:0016787 | Hydrolase activity | IEA | molecular_function |
| GO:0019901 | Protein kinase binding | IPI | molecular_function |
| GO:0032041 | NAD-dependent histone deacetylase activity (H3-K14 specific) | IEA | molecular_function |
| GO:0032703 | Negative regulation of interleukin-2 production | IDA | biological_process |
| GO:0033613 | Activating transcription factor binding | IPI | molecular_function |
| GO:0045668 | Negative regulation of osteoblast differentiation | IMP | biological_process |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
| GO:0046969 | NAD-dependent histone deacetylase activity (H3-K9 specific) | IEA | molecular_function |
| GO:0046970 | NAD-dependent histone deacetylase activity (H4-K16 specific) | IEA | molecular_function |
| GO:0070491 | Repressing transcription factor binding | IPI | molecular_function |
| GO:0071889 | 14-3-3 protein binding | IDA | molecular_function |
| GO:0090050 | Positive regulation of cell migration involved in sprouting angiogenesis | IMP | biological_process |
| GO:0097372 | NAD-dependent histone deacetylase activity (H3-K18 specific) | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9441497170 | 0.1553457809 | 0.9999902473 | 0.7621022520 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1513430817 |
| GSE13712_SHEAR | Down | -0.0352038788 |
| GSE13712_STATIC | Down | -0.1120870520 |
| GSE19018 | Down | -0.1427270997 |
| GSE19899_A1 | Down | -0.0852758447 |
| GSE19899_A2 | Down | -0.2566833960 |
| PubMed_21979375_A1 | Down | -0.4030994427 |
| PubMed_21979375_A2 | Down | -0.5052819120 |
| GSE35957 | Up | 0.1839666432 |
| GSE36640 | Down | -0.0610811437 |
| GSE54402 | Down | -0.1098295113 |
| GSE9593 | Down | -0.0429277197 |
| GSE43922 | Up | 0.0507072338 |
| GSE24585 | Down | -0.2155769948 |
| GSE37065 | Down | -0.3114933169 |
| GSE28863_A1 | Up | 0.3631061890 |
| GSE28863_A2 | Up | 0.1274208331 |
| GSE28863_A3 | Down | -0.0335572923 |
| GSE28863_A4 | Down | -0.0598992286 |
| GSE48662 | Up | 0.0035466350 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
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- Drugs
Name | Drug | Accession number |
|---|---|---|
| 7-[4-(Dimethylamino)Phenyl]-N-Hydroxy-4,6-Dimethyl-7-Oxo-2,4-Heptadienamide | DB04297 | EXPT03123 |
| Panobinostat | DB06603 | - |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-615-3p | MIMAT0003283 | MIRT040075 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-149-5p | MIMAT0000450 | MIRT045413 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 21120446 | Knockdown of HDAC7 resulted in significant G(1)/S arrest in different cancer cell lines |
| 21120446 | Of note, HDAC7 deficiency was further identified to induce cellular senescence program, which was also reversed by c-Myc re-expression |
| 21120446 | Further chromatin immunoprecipitation assays indicated that HDAC7 directly binds with c-Myc gene and HDAC7 silencing decreased c-Myc mRNA level via reducing histone H3/H4 acetylation and repressing the association of RNA polymerase II (RNAP II) with c-Myc gene |
| 21120446 | Further chromatin immunoprecipitation assays indicated that HDAC7 directly binds with c-Myc gene and HDAC7 silencing decreased c-Myc mRNA level via reducing histone H3/H4 acetylation and repressing the association of RNA polymerase II (RNAP II) with c-Myc gene |
| 21120446 | Taken together, our findings highlight for the first time an unrecognized link between HDAC7 and c-Myc and offer a novel mechanistic insight into the contribution of HDAC7 to tumor progression |
| 21120446 | Taken together, our findings highlight for the first time an unrecognized link between HDAC7 and c-Myc and offer a novel mechanistic insight into the contribution of HDAC7 to tumor progression |
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